Thermo-Responsive Hydrogels Containing Xenogenic Graft Materials for Bone Regeneration

被引：2

作者：

Kim, Jin ^{[1
]}

Cheon, Seo Young ^{[2
]}

Kook, Min Suk ^{[3
]}

Lee, Chang Moon ^{[4
]}

Lee, Ki Young ^{[5
]}

机构：

[1] Chonnam Natl Univ, Res Ctr Healthcare Biomed Engn, Yeosu 59626, South Korea

[2] Chonnam Natl Univ, Dept Adv Chem & Engn, Gwangju 61186, South Korea

[3] Chonnam Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Gwangju 61186, South Korea

[4] Chonnam Natl Univ, Dept Biomed Engn, Yeosu 59626, South Korea

[5] Chonnam Natl Univ, Fac Chem Engn, Gwangju 61186, South Korea

来源：

POLYMER-KOREA | 2018年 / 42卷 / 02期

关键词：

xenogenic bone graft material; methylcellulose; thermo-responsive; sol-gel; bone regeneration; ACID; RAT;

D O I：

10.7317/pk.2018.42.2.280

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Thermo-responsive hydrogels consisted of methylcellulose (MC) and xanthan gum (XT) could be used as an injectable reparing material to regenerate bone defect. In this study, the hydrogel containing xenogenic bone graft materials (BGM) was investigated for enhancement of bone defect regeneration in vivo. MC-XT aqueous solution containing BGM exhibited sol-to-gel transition at physiological temperature. In a cranial defect animal model studies, the hydrogel containing BGM improved the bone regeneration significantly in comparision with the untreated group and the hydrogel only group. As shown in the result of micro-CT and immunohistochemical staining, newly formed bone tissues were clearly observed at 4 weeks post-treatment in the hydrogel containing BGM group. The results indicate that the thermoresponsive MC-XT hydrogel containing BGM was an useful injectable material for bone defect regeneration in vivo.

引用

页码：280 / 287

页数：8

共 25 条

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