Powder diffractometric assay of two polymorphic forms of ranitidine hydrochloride

被引：35

作者：

Agatonovic-Kustrin, S ^{[1
]}

Wu, V ^{[1
]}

Rades, T ^{[1
]}

Saville, D ^{[1
]}

Tucker, IG ^{[1
]}

机构：

[1] Univ Otago, Sch Pharm, Dunedin, New Zealand

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1999年 / 184卷 / 01期

关键词：

ranitidine hydrochloride; polymorphism; artificial neural network; X-ray powder diffraction;

D O I：

10.1016/S0378-5173(99)00104-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A simple X-ray powder diffractometric method was developed for the qualitative and quantitative assay of the two crystalline modifications of ranitidine-HCl. The main purpose of the present work was to investigate if artificial neural networks (ANNs) could be applied in quantitative X-ray diffraetometric analyses. The ANN approach was compared with a conventional mixture design method. The results obtained by the ANN had a smaller standard deviation and relative error and a better precision at lower concentrations. ANNs provide a simple alternative to conventional statistical modelling methods to identify the non-linear relationship without complex equations. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：107 / 114

页数：8

共 20 条

[1] Solid-state investigation of fluocinolone acetonide [J].