A catalytic multicomponent coupling reaction for the enantioselective synthesis of spiroacetals

被引：97

作者：

Cala, Lara ^{[1
]}

Mendoza, Abraham ^{[1
]}

Fananas, Francisco J. ^{[1
]}

Rodriguez, Felix ^{[1
]}

机构：

[1] Univ Oviedo, Inst Univ Quim Organomet Enrique Moles, Oviedo 33006, Spain

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 26期

关键词：

NATURAL-PRODUCTS; TRANSFER HYDROGENATION; ASYMMETRIC-SYNTHESIS; SPIROKETALS; ACID; DERIVATIVES; CYCLIZATION; COMPLEXES; SCAFFOLDS; STRATEGY;

D O I：

10.1039/c3cc00118k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first multicomponent catalytic asymmetric synthesis of spiro-acetals has been described. Hybrid molecules comprising a spiro-acetal scaffold (a natural-product inspired scaffold) and an a-amino acid motif (a privileged fragment) are easily available through a gold phosphate-catalysed one-pot three component coupling reaction of alkynols, anilines and glyoxylic acid.

引用

收藏

页码：2715 / 2717

页数：3

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