Concordance between brain 18F-FDG PET and cerebrospinal fluid biomarkers in diagnosing Alzheimer's disease

被引：6
作者：
Rubi, S. [1 ,6 ]
Noguera, A. [2 ]
Tarongi, S. [3 ]
Oporto, M. [1 ]
Garcia, A. [3 ,4 ]
Vico, H. [3 ]
Espino, A.
Picado, M. J. [5 ]
Mas, A. [5 ]
Pena, C. [1 ,6 ]
Amer, G. [3 ,6 ]
机构：
[1] Hosp Univ Son Espases, Serv Med Nucl, Palma De Mallorca, Spain
[2] Hosp Univ Son Espases, Serv Anal Clin, Palma De Mallorca, Spain
[3] Hosp Univ Son Espases, Serv Neurol, Palma De Mallorca, Spain
[4] Hosp Son Llatzer, Serv Neurol, Palma De Mallorca, Spain
[5] Hosp Univ Son Espases, Serv Radiodiagnost, Palma De Mallorca, Spain
[6] Inst Invest Sanitaria Palma IdISPa, Palma De Mallorca, Spain
来源：
REVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR | 2018年 / 37卷 / 01期
关键词：
Alzheimer's disease; Cognitive impairment; PET; F-18-FDG; Cerebrospinal fluid; NATIONAL INSTITUTE; ASSOCIATION WORKGROUPS; CONSENSUS PAPER; TAU; VARIABILITY; PATHOPHYSIOLOGY; STANDARDIZATION; RECOMMENDATIONS; GUIDELINES; AGREEMENT;
D O I：
10.1016/j.remn.2017.05.003
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Objectives: Cortical posterior hypometabolism on PET imaging with F-18-FDG (FDG-PET), and altered levels of AB(1-42) peptide, total Tau (tTau) and phosphorylated Tau (pTau) proteins in cerebrospinal fluid (CSF) are established diagnostic biomarkers in Alzheimer's disease (AD). An evaluation has been made of the concordance and relationship between the results of FDG-PET and CSF biomarkers in symptomatic patients with suspected AD. Material and methods: A retrospective review was carried out on 120 patients with cognitive impairment referred to our Cognitive Neurology Unit, and who were evaluated by brain FDG-PET and a lumbar puncture for CSF biomarkers. In order to calculate their Kappa coefficient of concordance, the result of the FDG-PET and the set of the three CSF biomarkers in each patient was classified as normal, inconclusive, or AD-compatible. The relationship between the results of both methods was further assessed using logistic regression analysis, including the AB(1-42), tTau and pTau levels as quantitative predictors, and the FDG-PET result as the dependent variable. Results: The weighted Kappa coefficient between FDG-PET and CSF biomarkers was 0.46 (95% CI: 0.35-0.57). Logistic regression analysis showed that the AB(1-42) and tTau values together were capable of discriminating an FDG-PET result metabolically suggestive of AD from one non -suggestive of AD, with a 91% sensitivity and 93% specificity at the cut-off line AB(1-42) = 44+1.3 x tTau. Conclusions: The level of concordance between FDG-PET and CSF biomarkers was moderate, indicating their complementary value in diagnosing AD. The AB(1-42) and tTau levels in CSF help to predict the patient FDG-PET cortical metabolic status. (C) 2017 Elsevier Espana, S.L.U. y SEMNIM. All rights reserved.
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收藏
页码：3 / 8
页数：6
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