Bone marrow angiogenesis in systemic mast cell disease

被引:7
作者
Baek, JY
Li, CY
Pardanani, A
Butterfield, JH
Tefferi, A
机构
[1] Mayo Clin, Div Hematol & Internal Med, Rochester, MN 55905 USA
[2] Mayo Clin, Div Hematopathol, Rochester, MN 55905 USA
[3] Mayo Clin, Div Allerg Dis & Internal Med, Rochester, MN 55905 USA
来源
JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH | 2002年 / 11卷 / 01期
关键词
D O I
10.1089/152581602753448603
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Mast cells may participate in tumor angiogenesis through the release of angiogenic cytokines from their secretory granules. To gain additional insight into the role of mast cells in bone marrow angiogenesis, we performed a semiquantitative measurement of bone marrow microvessel density in 52 consecutive adult patients with systemic mast cell disease (SMCD). The results were examined for potential correlations with mast cell expression of angiogenic cytokines and with other histologic features of the bone marrow. Standard immunohistochemical methods were used to visualize bone marrow microvessels (CD34 staining) and mast cell expression of transforming growth factor-beta, basic fibroblast growth factor, and their respective receptors. An increase in microvessel density was demonstrated in 32 of the 52 patients (62%) with SMCD, and the degree of bone marrow angiogenesis did not correlate with either the mast cell expression pattern of the study cytokines or the presence (23 patients) or absence (29 patients) of an associated hematologic disorder. In the 29 patients without an associated hematologic disorder, microvessel density was correlated significantly with the presence of an abnormal pattern of hematopoiesis but not with the degree of bone marrow involvement by mast cells. Furthermore, areas occupied by mast cell lesions were often devoid of neovascularization. We conclude that bone marrow angiogenesis characterizes a percentage of patients with SMCD and that the pathogenesis may not necessarily be linked to the mast cells themselves.
引用
收藏
页码:139 / 146
页数:8
相关论文
共 49 条
[1]  
AGIS H, 1993, J IMMUNOL, V151, P4221
[2]   Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes [J].
Aguayo, A ;
Kantarjian, H ;
Manshouri, T ;
Gidel, C ;
Estey, E ;
Thomas, D ;
Koller, C ;
Estrov, Z ;
O'Brien, S ;
Keating, M ;
Freireich, E ;
Albitar, M .
BLOOD, 2000, 96 (06) :2240-2245
[3]   Analysis of the surface expression of c-kit and occurrence of the c-kit Asp816Val activating mutation in T cells, B cells, and myelomonocytic cells in patients with mastocytosis [J].
Akin, C ;
Kirshenbaum, AS ;
Semere, T ;
Worobec, AS ;
Scott, LM ;
Metcalfe, DD .
EXPERIMENTAL HEMATOLOGY, 2000, 28 (02) :140-147
[4]   Paraffin section detection of the c-kit gene product (CD117) in human tissues:: Value in the diagnosis of mast cell disorders [J].
Arber, DA ;
Tamayo, R ;
Weiss, LM .
HUMAN PATHOLOGY, 1998, 29 (05) :498-504
[5]   Human mast cells stimulate vascular tribe formation - Tryptase is a novel, potent angiogenic factor [J].
Blair, RJ ;
Meng, H ;
Marchese, MJ ;
Ren, SL ;
Schwartz, LB ;
Tonnesen, MG ;
Gruber, BL .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (11) :2691-2700
[6]   Mast cells can secrete vascular permeability factor vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of Fcε receptor I expression [J].
Boesiger, J ;
Tsai, M ;
Maurer, M ;
Yamaguchi, M ;
Brown, LF ;
Claffey, KP ;
Dvorak, HF ;
Galli, SJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (06) :1135-1145
[7]   Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis:: A possible explanation for divergent clinical behavior [J].
Büttner, C ;
Henz, BM ;
Welker, P ;
Sepp, NT ;
Grabbe, J .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 111 (06) :1227-1231
[8]   Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis [J].
Coussens, LM ;
Raymond, WW ;
Bergers, G ;
Laig-Webster, M ;
Behrendtsen, O ;
Werb, Z ;
Caughey, GH ;
Hanahan, D .
GENES & DEVELOPMENT, 1999, 13 (11) :1382-1397
[9]   MASTOCYTOSIS SYNDROME - CLINICAL AND BIOLOGICAL STUDIES [J].
DEMIS, DJ .
ANNALS OF INTERNAL MEDICINE, 1963, 59 (02) :194-+
[10]  
DETHLEFSEN SM, 1994, INVAS METAST, V14, P395