T Helper 1 Cytokines and Their Relationship with Beta Cell Function in Type 1 Diabetes

被引:0
作者
Tamer, Gonca [1 ]
Isbilen Basok, Banu [2 ]
Dogan, Burcu [3 ]
Telci Caklili, Ozge [4 ]
Kostek, Osman [5 ]
机构
[1] Istanbul Medeniyet Univ, Div Endocrinol & Metab, Goztepe Training & Res Hosp, Istanbul, Turkey
[2] Univ Hlth Sci, Izmir Tepecik Training & Res Hosp, Dept Biochem, Izmir, Turkey
[3] Istanbul Medeniyet Univ, Dept Family Med, Goztepe Training & Res Hosp, Istanbul, Turkey
[4] Istanbul Univ, Dept Endocrinol & Metab, Fac Med, Istanbul, Turkey
[5] Trakya Univ, Dept Oncol, Fac Med, Edirne, Turkey
关键词
Type; 1; diabetes; IFN-gamma; IL-2; TNF-alpha; T helper-1 cell; INTERFERON-GAMMA; GLYCEMIC CONTROL; INFLAMMATION; ASSOCIATION; PATHOGENESIS; INSULITIS; MELLITUS; CHILDREN; AGE;
D O I
10.25179/tjem.2019-71070
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: In type 1 diabetes (T1D), T helper (Th) 1 cells affect beta cell functions significantly. This study aims to explore the association between serum levels of Th1 cytokines [interferon-gamma (IFN-gamma), interleukin (IL)-2 and tumor necrosis factor-alpha (TNF-alpha)] and beta cell function in T1D. Material and Methods: The study included 110 patients with T1D (TIDPs) and 31 healthy controls. The beta cell functions in T1DPS were assessed by calculating mixed-meal stimulated C-peptide levels. T1DPs were categorized into three groups depending on results of this test (1a-lowest, 1b, 1c-highest). Cytokine levels, IFN-gamma/IL-2, and TNF-alpha/IL-2 ratios in T1DPs were compared with that in controls. Correlation analysis between cytokine levels and diabetes-related parameters was then carried out. Results: IFN-gamma, TNF-alpha, IL-2 levels, and TNF-alpha/IL-2 of T1DPs were higher (p=0.02, p=0.01, p=0.008, and p=0.01, respectively) than that of controls. The highest IFN-gamma/IL-2 and TNF-alpha/IL-2 ratios were observed in group 1b (p=0.03 and p=0.04, respectively) while the lowest IFN-gamma/IL-2 and TNF-alpha/IL-2 ratios were observed in group 1a (p=0.03 and p=0.04, respectively). The TNF-alpha levels were found to be negatively correlated with fasting glucose levels (r(2) =-0.003, p=0.031). However, after adjustment for age and gender, this correlation diminished (r(2) =-0.028, p=0.076). Conclusion: IFN-gamma, IL-2, and TNF-alpha may exhibit a triggering role in the pathogenesis of T1D. IFN-gamma/IL-2 and TNF-alpha/IL-2 ratios possibly have more significant roles in the progression of beta cell dysfunction than other cytokines.
引用
收藏
页码:177 / 183
页数:7
相关论文
共 50 条
[41]   Editorial: Heterogeneity of clinical phenotypes in type 1 diabetes and of beta cell deterioration in type 1 diabetes [J].
Li, Xia ;
Zhang, Mei ;
Yan, Jinhua ;
Liu, Zhenqi .
FRONTIERS IN ENDOCRINOLOGY, 2023, 13
[42]   The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes [J].
Szabo, Csilla Eniko ;
Ilies, Roxana Flavia ;
Aioanei, Casian Simon ;
Catana, Andreea ;
Cret, Victoria ;
Serban, Radu Sorin ;
Pop, Ioan Victor .
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2019, 12 :2303-2308
[43]   Do post-translational beta cell protein modifications trigger type 1 diabetes? [J].
Storling, Joachim ;
Overgaard, Anne Julie ;
Brorsson, Caroline Anna ;
Piva, Francesco ;
Bang-Berthelsen, Claus Heiner ;
Haase, Claus ;
Nerup, Jorn ;
Pociot, Flemming .
DIABETOLOGIA, 2013, 56 (11) :2347-2354
[44]   Enhanced expression of type 1 helper T-cell cytokines in the myocardium of active cardiac sarcoidosis [J].
Terasaki, Fumio ;
Ukimura, Akira ;
Tsukada, Bin ;
Fujita, Shuichi ;
Katashima, Takashi ;
Otsuka, Kaoru ;
Otsuka, Koji ;
Kanzaki, Yumiko ;
Shimomura, Hiroaki ;
Fujita, Masatoshi ;
Tanaka, Takao ;
Kitaura, Yasushi .
CIRCULATION JOURNAL, 2008, 72 (08) :1303-1307
[45]   Vitamin D status and the predictors of circulating T helper 1-type immunoglobulin levels in Iranian subjects with type 1 diabetes and their siblings: a case-control study [J].
Ghandchi, Z. ;
Neyestani, T. R. ;
Yaraghi, A. -A. Saboor ;
Eshraghian, M. -R. ;
Gharavi, A. ;
Shariatzadeh, N. ;
Kalayi, A. ;
Houshiarrad, A. .
JOURNAL OF HUMAN NUTRITION AND DIETETICS, 2012, 25 (04) :365-372
[46]   Serum Cytokines and Growth Factors in Subjects with Type 1 Diabetes: Associations with Time in Ranges and Glucose Variability [J].
Klimontov, Vadim V. ;
Mavlianova, Kamilla R. ;
Orlov, Nikolai B. ;
Semenova, Julia F. ;
Korbut, Anton I. .
BIOMEDICINES, 2023, 11 (10)
[47]   Insulin Resistance in Adolescents with Type 1 Diabetes and Its Relationship to Cardiovascular Function [J].
Nadeau, Kristen J. ;
Regensteiner, Judith G. ;
Bauer, Timothy A. ;
Brown, Mark S. ;
Dorosz, Jennifer L. ;
Hull, Amber ;
Zeitler, Phil ;
Draznin, Boris ;
Reusch, Jane E. B. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (02) :513-521
[48]   T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes [J].
Burrack, Adam L. ;
Martinov, Tijana ;
Fife, Brian T. .
FRONTIERS IN ENDOCRINOLOGY, 2017, 8
[49]   Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes [J].
Moin, Abu Saleh Md ;
Butler, Alexandra E. .
CURRENT DIABETES REPORTS, 2019, 19 (09)
[50]   Improved T cell assay for identification of type 1 diabetes patients [J].
Brooks-Worrell, Barbara ;
Warsen, Adelaide ;
Palmer, Jerfy P. .
JOURNAL OF IMMUNOLOGICAL METHODS, 2009, 344 (01) :79-83