Biotechnology in reproductive medicine

被引：5

作者：

Illmensee, K ^{[1
]}

机构：

[1] Univ Innsbruck, Dept Gynecol & Obstet, A-6020 Innsbruck, Austria

来源：

DIFFERENTIATION | 2002年 / 69卷 / 4-5期

关键词：

pharmaceutical cloning; transgenic mammals; therapeutic cloning; stem cells; reproductive cloning; mammalian embryology; assisted reproduction;

D O I：

10.1046/j.1432-0436.2002.690407.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this review I am summarizing the past and current progress in the field of pharmaceutical, diagnostic, therapeutic, and reproductive cloning in mammals. Several human gene products can be pharmaceutically explored in transgenic farm animals and employed for medical applications. Preimplantation genetic diagnosis (PGD) is utilizing modern molecular cloning techniques to detect genetic and chromosomal aberrations in early embryos originating from patients with inborn errors at risk for hereditary diseases or age-related risk for abnormal karyotype. Stem cell engineering from early human embryos is creating new and promising but also controversial applications for therapeutic and regenerative medicine. Potential risk factors for reproductive cloning are presented and discussed in the context of possible developmental malformations, frequently observed after embryo culture and cloning in farm animals. Future extension of biotechnology p human reproductive cloning is currently under worldwide dispute.

引用

页码：167 / 173

页数：7

共 49 条

[1] Stem cell therapy and gene transfer for regeneration [J].

Asahara, T ;

Kalka, C ;

Isner, JM .

GENE THERAPY, 2000, 7 (06) :451-457

[2] BIRTH OF LARGE CALVES THAT DEVELOPED FROM IN VITRO-DERIVED BOVINE EMBRYOS [J].

BEHBOODI, E ;

ANDERSON, GB ;

BONDURANT, RH ;

CARGILL, SL ;

KREUSCHER, BR ;

MEDRANO, JF ;

MURRAY, JD .

THERIOGENOLOGY, 1995, 44 (02) :227-232

[3] Extension of life-span by introduction of telomerase into normal human cells [J].

Bodnar, AG ;

Ouellette, M ;

Frolkis, M ;

Holt, SE ;

Chiu, CP ;

Morin, GB ;

Harley, CB ;

Shay, JW ;

Lichtsteiner, S ;

Wright, WE .

SCIENCE, 1998, 279 (5349) :349-352

[4]

CIBELLI JB, 2001, J REGEN MED, V2

[5] The human pluripotent stem cell: impact on medicine and society [J].

Edwards, BE ;

Gearhart, JD ;

Wallach, EE .

FERTILITY AND STERILITY, 2000, 74 (01) :1-7

[6] Mitochondrial DNA genotypes in nuclear transfer-derived cloned sheep [J].

Evans, MJ ;

Gurer, C ;

Loike, JD ;

Wilmut, I ;

Schnieke, AE ;

Schon, EA .

NATURE GENETICS, 1999, 23 (01) :90-93

[7] Nuclear transplantation in mammals: Remodelling of transplanted nuclei under the influence of maturation promoting factor [J].

Fulka, J ;

First, NL ;

Moor, RM .

BIOESSAYS, 1996, 18 (10) :835-840

[8]

GILLS ES, 2001, J ASSIST REPROD GEN, V18, P468

[9]

HALL JL, 1993, ASSIST REPROD REV, V3, P129

[10] PREGNANCIES FROM BIOPSIED HUMAN PREIMPLANTATION EMBRYOS SEXED BY Y-SPECIFIC DNA AMPLIFICATION [J].

HANDYSIDE, AH ;

KONTOGIANNI, EH ;

HARDY, K ;

WINSTON, RML .

NATURE, 1990, 344 (6268) :768-770

← 1 2 3 4 5 →