One-pot synthesis of antiviral acyclovir and other nucleosides derivatives using doped natural phosphate as lewis acid catalyst

被引：9

作者：

Lazrek, Hassan B. ^{[1
]}

Baddi, Laila ^{[1
]}

Smietana, Michael ^{[2
]}

Vasseur, Jean-Jacques ^{[2
]}

Sebti, Said ^{[3
]}

Zahouily, Mohamed ^{[4
]}

机构：

[1] Fac Sci Semlalia, Unite Chim Biomol & Med, Marrakech, Morocco

[2] Univ Montpellier 2, Univ Montpellier 1, Inst Biomol Max Mousseron, CNRS UMR 5247, Montpellier, France

[3] Fac Sci Ben MSik, Lab Chim Organ Catalyse & Environm, Casablanca, Morocco

[4] Fac Sci & Tech, Lab Catalyse Chimiometrie & Environm, Mohammadia, Morocco

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2008年 / 27卷 / 10-11期

关键词：

acyclovir natural phosphate; Lewis acid catalyst;

D O I：

10.1080/15257770802341285

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural phosphate doped with iodine or potassium iodide is an active catalyst for the one-pot synthesis of acyclonucleosides. To demonstrate the utility of the new catalyst system, the highly important antiviral drug acyclovir was directly and regioselectively obtained from NAcG with no byproducts.

引用

页码：1107 / 1112

页数：6

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