Copper-catalyzed C(sp3)-H functionalization of ketones with vinyl azides: synthesis of substituted-1H-pyrroles

被引：32

作者：

Donthiri, Ramachandra Reddy ^{[1
]}

Samanta, Supravat ^{[1
]}

Adimurthy, Subbarayappa ^{[1
]}

机构：

[1] CSIR, Cent Salt & Marine Chem Res Inst, Acad Sci & Innovat Res Proc Design & Engn Cell, Bhavnagar 364002, Gujarat, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 40期

关键词：

H BOND FUNCTIONALIZATION; PYRROLE SYNTHESIS; 3+2 CYCLOADDITION; REGIOSELECTIVE SYNTHESIS; SUBSTITUTED PYRROLES; OXIDATIVE LINKAGE; C-N; ALKYNES; FACILE; 2H-AZIRINES;

D O I：

10.1039/c5ob01407g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed C(sp(3))-H functionalization of ketones with vinyl azides for the synthesis of substituted pyrroles has been developed. The method is a straightforward and efficient way to access a series of 2,3,5-trisubstituted-1H-pyrroles in modest to excellent yields with broad functional group tolerance under mild conditions.

引用

页码：10113 / 10116

页数：4

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