Plasminogen Activator Inhibitor-1 in Cancer: Rationale and Insight for Future Therapeutic Testing

被引：150
作者：
Placencio, Veronica R. [1 ,2 ]
DeClerck, Yves A. [1 ,2 ,3 ]
机构：
[1] Univ So Calif, Dept Pediat, Div Hematol Oncol & Blood & Bone Marrow Transplan, Los Angeles, CA 90089 USA
[2] Childrens Hosp Los Angeles, Saban Res Inst, Los Angeles, CA 90027 USA
[3] Univ So Calif, Dept Biochem & Mol Biol, Los Angeles, CA USA
来源：
CANCER RESEARCH | 2015年 / 75卷 / 15期
基金：
美国国家卫生研究院;
关键词：
FIBROSARCOMA CELLS; PAI-1; INHIBITOR; BREAST-CANCER; TUMOR-GROWTH; WILD-TYPE; UROKINASE; TYPE-1; ANGIOGENESIS; DEFICIENT; BINDING;
D O I：
10.1158/0008-5472.CAN-15-0876
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite its function as an inhibitor of urokinase and tissue-type plasminogen activator (PA), PA inhibitor-1 (PAI-1) has a paradoxical protumorigenic role in cancer, promoting angiogenesis and tumor cell survival. In this review, we summarize preclinical evidence in support of the protumorigenic function of PAI-1 that has led to the testing of small-molecule PAI-1 inhibitors, initially developed as antithrombotic agents, in animal models of cancer. The review discusses the challenges and the opportunities that lay ahead to the development of efficacious and nontoxic PAI-1 inhibitors as anticancer agents. (C) 2015 AACR.
引用
收藏
页码：2969 / 2974
页数：6
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