共 62 条
Citrullination under physiological and pathological conditions
被引:102
作者:

Baka, Zsuzsanna
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h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary

Gyoergy, Bence
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary

Geher, Pal
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Rheumatol, H-1023 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary

Buzas, Edit I.
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary

Falus, Andras
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h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary

Nagy, Gyoergy
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
Semmelweis Univ, Dept Rheumatol, H-1023 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
机构:
[1] Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
[2] Semmelweis Univ, Dept Rheumatol, H-1023 Budapest, Hungary
关键词:
Citrullination;
Smoking;
Rheumatoid arthritis;
Tumorigenesis;
Peptidylarginine deiminase;
Gene regulation;
Anti-citrullinated protein antibodies;
RHEUMATOID-ARTHRITIS;
PEPTIDYLARGININE-DEIMINASE;
MULTIPLE-SCLEROSIS;
ALPHA-ENOLASE;
TISSUE INFLAMMATION;
AUTOIMMUNE-RESPONSE;
PADI4;
EXPRESSION;
GENE-EXPRESSION;
TRANSGENIC MICE;
DISEASE;
D O I:
10.1016/j.jbspin.2012.01.008
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Citrullination, one of the enzymatic posttranslational modifications has become a hot topic of recent research as it is involved in various physiological and pathological processes. Antibodies against citrullinated proteins called anti-citrullinated protein antibodies, are the hallmark (diagnostic and prognostic factors) of rheumatoid arthritis, and are specific for the disease. Citrullination has an important role in the normal function of the immune system, skin keratinization, the insulation of neurons and the plasticity of the central nervous system including its essential role in gene regulation. Abnormal citrullination has been proposed to play a role in multiple sclerosis and Alzheimer's disease, and recent research has drawn attention to its implication in tumorigenesis. Still, it is unclear whether citrullination is the cause or the consequence of these pathological alterations. Here, we discuss crucial aspects of citrullination during both physiological and pathological conditions. (C) 2012 Published by Elsevier Masson SAS on behalf of the Societe Francaise de Rhumatologie.
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页码:431 / 436
页数:6
相关论文
共 62 条
[1]
Antibodies against cyclic citrullinated peptide (CCP) in psoriatic patients with or without joint inflammation
[J].
Alenius, GM
;
Berglin, E
;
Dahlqvist, SR
.
ANNALS OF THE RHEUMATIC DISEASES,
2006, 65 (03)
:398-400

Alenius, GM
论文数: 0 引用数: 0
h-index: 0
机构:
Umea Univ Hosp, Dept Publ Hlth & Clin Med, SE-90185 Umea, Sweden Umea Univ Hosp, Dept Publ Hlth & Clin Med, SE-90185 Umea, Sweden

Berglin, E
论文数: 0 引用数: 0
h-index: 0
机构:
Umea Univ Hosp, Dept Publ Hlth & Clin Med, SE-90185 Umea, Sweden Umea Univ Hosp, Dept Publ Hlth & Clin Med, SE-90185 Umea, Sweden

Dahlqvist, SR
论文数: 0 引用数: 0
h-index: 0
机构:
Umea Univ Hosp, Dept Publ Hlth & Clin Med, SE-90185 Umea, Sweden Umea Univ Hosp, Dept Publ Hlth & Clin Med, SE-90185 Umea, Sweden
[2]
Specific expression of PAD4 and citrullinated proteins in lung cancer is not associated with anti-CCP antibody production
[J].
Baka, Zsuzsanna
;
Barta, Peter
;
Losonczy, Gyoergy
;
Krenacs, Tibor
;
Papay, Judit
;
Szarka, Eszter
;
Sarmay, Gabriella
;
Babos, Fruzsina
;
Magyar, Anna
;
Geher, Pal
;
Buzas, Edit I.
;
Nagy, Gyoergy
.
INTERNATIONAL IMMUNOLOGY,
2011, 23 (06)
:405-414

Baka, Zsuzsanna
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

Barta, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Pulmonol, H-1125 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

Losonczy, Gyoergy
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Pulmonol, H-1125 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

Krenacs, Tibor
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Pathol, H-1085 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

Papay, Judit
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Pathol, H-1085 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

Szarka, Eszter
论文数: 0 引用数: 0
h-index: 0
机构:
Eotvos Lorand Univ, Hungarian Acad Sci, Dept Immunol, H-1117 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

Sarmay, Gabriella
论文数: 0 引用数: 0
h-index: 0
机构:
Eotvos Lorand Univ, Hungarian Acad Sci, Dept Immunol, H-1117 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

Babos, Fruzsina
论文数: 0 引用数: 0
h-index: 0
机构:
Eotvos Lorand Univ, Hungarian Acad Sci, Res Grp Peptide Chem, H-1117 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

Magyar, Anna
论文数: 0 引用数: 0
h-index: 0
机构:
Eotvos Lorand Univ, Hungarian Acad Sci, Res Grp Peptide Chem, H-1117 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

Geher, Pal
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Rheumatol, H-1023 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

Buzas, Edit I.
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

Nagy, Gyoergy
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary
Semmelweis Univ, Dept Rheumatol, H-1023 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary
[3]
Rheumatoid arthritis and smoking: putting the pieces together
[J].
Baka, Zsuzsanna
;
Buzas, Edit
;
Nagy, Gyoergy
.
ARTHRITIS RESEARCH & THERAPY,
2009, 11 (04)
:238

Baka, Zsuzsanna
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1445 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1445 Budapest, Hungary

Buzas, Edit
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1445 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1445 Budapest, Hungary

Nagy, Gyoergy
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1445 Budapest, Hungary
Semmelweis Univ, Dept Rheumatol, H-1023 Budapest, Hungary Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1445 Budapest, Hungary
[4]
Pulmonary dysfunction, smoking, socioeconomic status and the risk of developing rheumatoid arthritis
[J].
Bergstrom, Ulf
;
Jacobsson, Lennart T. H.
;
Nilsson, Jan-Ake
;
Berglund, Goran
;
Turesson, Carl
.
RHEUMATOLOGY,
2011, 50 (11)
:2005-2013

Bergstrom, Ulf
论文数: 0 引用数: 0
h-index: 0
机构:
Lund Univ, Rheumatol Sect, Dept Clin Sci, Malmo, Sweden Lund Univ, Rheumatol Sect, Dept Clin Sci, Malmo, Sweden

Jacobsson, Lennart T. H.
论文数: 0 引用数: 0
h-index: 0
机构:
Lund Univ, Rheumatol Sect, Dept Clin Sci, Malmo, Sweden Lund Univ, Rheumatol Sect, Dept Clin Sci, Malmo, Sweden

Nilsson, Jan-Ake
论文数: 0 引用数: 0
h-index: 0
机构:
Lund Univ, Rheumatol Sect, Dept Clin Sci, Malmo, Sweden Lund Univ, Rheumatol Sect, Dept Clin Sci, Malmo, Sweden

Berglund, Goran
论文数: 0 引用数: 0
h-index: 0
机构:
Lund Univ, Dept Clin Sci, Malmo, Sweden Lund Univ, Rheumatol Sect, Dept Clin Sci, Malmo, Sweden

Turesson, Carl
论文数: 0 引用数: 0
h-index: 0
机构:
Lund Univ, Rheumatol Sect, Dept Clin Sci, Malmo, Sweden Lund Univ, Rheumatol Sect, Dept Clin Sci, Malmo, Sweden
[5]
Rheumatoid arthritis and periodontal disease
[J].
Berthelot, Jean-Marie
;
Le Goff, Benoit
.
JOINT BONE SPINE,
2010, 77 (06)
:537-541

Berthelot, Jean-Marie
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Nantes, Hotel Dieu, Serv Rhumatol, F-44093 Nantes 01, France CHU Nantes, Hotel Dieu, Serv Rhumatol, F-44093 Nantes 01, France

Le Goff, Benoit
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Nantes, Hotel Dieu, Serv Rhumatol, F-44093 Nantes 01, France CHU Nantes, Hotel Dieu, Serv Rhumatol, F-44093 Nantes 01, France
[6]
Neutrophil extracellular traps kill bacteria
[J].
Brinkmann, V
;
Reichard, U
;
Goosmann, C
;
Fauler, B
;
Uhlemann, Y
;
Weiss, DS
;
Weinrauch, Y
;
Zychlinsky, A
.
SCIENCE,
2004, 303 (5663)
:1532-1535

Brinkmann, V
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Infect Biol, Dept Cellular Microbiol, D-10117 Berlin, Germany

Reichard, U
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Infect Biol, Dept Cellular Microbiol, D-10117 Berlin, Germany

Goosmann, C
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Infect Biol, Dept Cellular Microbiol, D-10117 Berlin, Germany

Fauler, B
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Infect Biol, Dept Cellular Microbiol, D-10117 Berlin, Germany

Uhlemann, Y
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Infect Biol, Dept Cellular Microbiol, D-10117 Berlin, Germany

Weiss, DS
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Infect Biol, Dept Cellular Microbiol, D-10117 Berlin, Germany

Weinrauch, Y
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Infect Biol, Dept Cellular Microbiol, D-10117 Berlin, Germany

Zychlinsky, A
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Infect Biol, Dept Cellular Microbiol, D-10117 Berlin, Germany
[7]
Increased PADI4 expression in blood and tissues of patients with malignant tumors
[J].
Chang, Xiaotian
;
Han, Jinxiang
;
Pang, Li
;
Zhao, Yan
;
Yang, Yi
;
Shen, Zhonglin
.
BMC CANCER,
2009, 9

Chang, Xiaotian
论文数: 0 引用数: 0
h-index: 0
机构:
Shandong Acad Med Sci, Key Lab Biodrugs Minist Hlth, Med Biotechnol Res Ctr, Jinan 250062, Shandong, Peoples R China Shandong Acad Med Sci, Key Lab Biodrugs Minist Hlth, Med Biotechnol Res Ctr, Jinan 250062, Shandong, Peoples R China

Han, Jinxiang
论文数: 0 引用数: 0
h-index: 0
机构:
Shandong Acad Med Sci, Key Lab Biodrugs Minist Hlth, Med Biotechnol Res Ctr, Jinan 250062, Shandong, Peoples R China Shandong Acad Med Sci, Key Lab Biodrugs Minist Hlth, Med Biotechnol Res Ctr, Jinan 250062, Shandong, Peoples R China

Pang, Li
论文数: 0 引用数: 0
h-index: 0
机构:
Shandong Univ, Sch Med, Shandong Univ Hosp 2, Jinan 250100, Shandong, Peoples R China Shandong Acad Med Sci, Key Lab Biodrugs Minist Hlth, Med Biotechnol Res Ctr, Jinan 250062, Shandong, Peoples R China

Zhao, Yan
论文数: 0 引用数: 0
h-index: 0
机构:
Shandong Acad Med Sci, Key Lab Biodrugs Minist Hlth, Med Biotechnol Res Ctr, Jinan 250062, Shandong, Peoples R China Shandong Acad Med Sci, Key Lab Biodrugs Minist Hlth, Med Biotechnol Res Ctr, Jinan 250062, Shandong, Peoples R China

Yang, Yi
论文数: 0 引用数: 0
h-index: 0
机构:
Yankuang Hosp Yanzhou, Yangzhou, Shandong, Peoples R China Shandong Acad Med Sci, Key Lab Biodrugs Minist Hlth, Med Biotechnol Res Ctr, Jinan 250062, Shandong, Peoples R China

Shen, Zhonglin
论文数: 0 引用数: 0
h-index: 0
机构:
Yankuang Hosp Yanzhou, Yangzhou, Shandong, Peoples R China Shandong Acad Med Sci, Key Lab Biodrugs Minist Hlth, Med Biotechnol Res Ctr, Jinan 250062, Shandong, Peoples R China
[8]
Expression of peptidylarginine deiminase type 4 (PAD4) in various tumors
[J].
Chang, XT
;
Han, JX
.
MOLECULAR CARCINOGENESIS,
2006, 45 (03)
:183-196

Chang, XT
论文数: 0 引用数: 0
h-index: 0
机构: Shandong Acad Med Sci, Med Biotechnol Ctr, Shandong, Peoples R China

Han, JX
论文数: 0 引用数: 0
h-index: 0
机构: Shandong Acad Med Sci, Med Biotechnol Ctr, Shandong, Peoples R China
[9]
Functional Connection between Deimination and Deacetylation of Histones
[J].
Denis, Helene
;
Deplus, Rachel
;
Putmans, Pascale
;
Yamada, Michiyuki
;
Metivier, Raphael
;
Fuks, Francois
.
MOLECULAR AND CELLULAR BIOLOGY,
2009, 29 (18)
:4982-4993

Denis, Helene
论文数: 0 引用数: 0
h-index: 0
机构:
Free Univ Brussels, Fac Med, Lab Canc Epigenet, B-1070 Brussels, Belgium Free Univ Brussels, Fac Med, Lab Canc Epigenet, B-1070 Brussels, Belgium

Deplus, Rachel
论文数: 0 引用数: 0
h-index: 0
机构:
Free Univ Brussels, Fac Med, Lab Canc Epigenet, B-1070 Brussels, Belgium Free Univ Brussels, Fac Med, Lab Canc Epigenet, B-1070 Brussels, Belgium

Putmans, Pascale
论文数: 0 引用数: 0
h-index: 0
机构:
Free Univ Brussels, Fac Med, Lab Canc Epigenet, B-1070 Brussels, Belgium Free Univ Brussels, Fac Med, Lab Canc Epigenet, B-1070 Brussels, Belgium

Yamada, Michiyuki
论文数: 0 引用数: 0
h-index: 0
机构:
Yokohama City Univ, Grad Sch Integrated Sci, Kanazawa Ku, Yokohama, Kanagawa 2360027, Japan Free Univ Brussels, Fac Med, Lab Canc Epigenet, B-1070 Brussels, Belgium

Metivier, Raphael
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rennes 1, Equipe SPARTE, CNRS, UMR 6026, F-35042 Rennes, France Free Univ Brussels, Fac Med, Lab Canc Epigenet, B-1070 Brussels, Belgium

Fuks, Francois
论文数: 0 引用数: 0
h-index: 0
机构:
Free Univ Brussels, Fac Med, Lab Canc Epigenet, B-1070 Brussels, Belgium Free Univ Brussels, Fac Med, Lab Canc Epigenet, B-1070 Brussels, Belgium
[10]
Citrullination of Linear and Cyclic Altered Peptide Ligands from Myelin Basic Protein (MBP87-99) Epitope Elicits a Th1 Polarized Response by T Cells Isolated from Multiple Sclerosis Patients: Implications in Triggering Disease
[J].
Deraos, George
;
Chatzantoni, Kokona
;
Matsoukas, Minos-Timotheos
;
Tselios, Theodore
;
Deraos, Spyros
;
Katsara, Maria
;
Papathanasopoulos, Panagiotis
;
Vynios, Demitrios
;
Apostolopoulos, Vasso
;
Mouzaki, Athanasia
;
Matsoukas, John
.
JOURNAL OF MEDICINAL CHEMISTRY,
2008, 51 (24)
:7834-7842

Deraos, George
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Patras, Dept Chem, Patras 26500, Greece Burnet Inst, Immunol & Vaccine Lab, Heidelberg, Vic 3084, Australia

Chatzantoni, Kokona
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Patras, Sch Med, Dept Internal Med, Div Hematol, GR-26110 Patras, Greece Burnet Inst, Immunol & Vaccine Lab, Heidelberg, Vic 3084, Australia

Matsoukas, Minos-Timotheos
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Patras, Dept Chem, Patras 26500, Greece Burnet Inst, Immunol & Vaccine Lab, Heidelberg, Vic 3084, Australia

Tselios, Theodore
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Patras, Dept Chem, Patras 26500, Greece Burnet Inst, Immunol & Vaccine Lab, Heidelberg, Vic 3084, Australia

Deraos, Spyros
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Patras, Dept Chem, Patras 26500, Greece Burnet Inst, Immunol & Vaccine Lab, Heidelberg, Vic 3084, Australia

Katsara, Maria
论文数: 0 引用数: 0
h-index: 0
机构:
Burnet Inst, Immunol & Vaccine Lab, Heidelberg, Vic 3084, Australia
Univ Patras, Dept Chem, Patras 26500, Greece Burnet Inst, Immunol & Vaccine Lab, Heidelberg, Vic 3084, Australia

Papathanasopoulos, Panagiotis
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Patras, Med Sch & Univ Hosp, Patras 26500, Greece Burnet Inst, Immunol & Vaccine Lab, Heidelberg, Vic 3084, Australia

Vynios, Demitrios
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Patras, Dept Chem, Patras 26500, Greece Burnet Inst, Immunol & Vaccine Lab, Heidelberg, Vic 3084, Australia

Apostolopoulos, Vasso
论文数: 0 引用数: 0
h-index: 0
机构:
Burnet Inst, Immunol & Vaccine Lab, Heidelberg, Vic 3084, Australia Burnet Inst, Immunol & Vaccine Lab, Heidelberg, Vic 3084, Australia

Mouzaki, Athanasia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Patras, Sch Med, Dept Internal Med, Div Hematol, GR-26110 Patras, Greece Burnet Inst, Immunol & Vaccine Lab, Heidelberg, Vic 3084, Australia

Matsoukas, John
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Patras, Dept Chem, Patras 26500, Greece Burnet Inst, Immunol & Vaccine Lab, Heidelberg, Vic 3084, Australia