Citrullination under physiological and pathological conditions

被引:102
作者
Baka, Zsuzsanna [1 ]
Gyoergy, Bence [1 ]
Geher, Pal [2 ]
Buzas, Edit I. [1 ]
Falus, Andras [1 ]
Nagy, Gyoergy [1 ,2 ]
机构
[1] Semmelweis Univ, Dept Genet Cell & Immunobiol, Budapest, Hungary
[2] Semmelweis Univ, Dept Rheumatol, H-1023 Budapest, Hungary
关键词
Citrullination; Smoking; Rheumatoid arthritis; Tumorigenesis; Peptidylarginine deiminase; Gene regulation; Anti-citrullinated protein antibodies; RHEUMATOID-ARTHRITIS; PEPTIDYLARGININE-DEIMINASE; MULTIPLE-SCLEROSIS; ALPHA-ENOLASE; TISSUE INFLAMMATION; AUTOIMMUNE-RESPONSE; PADI4; EXPRESSION; GENE-EXPRESSION; TRANSGENIC MICE; DISEASE;
D O I
10.1016/j.jbspin.2012.01.008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Citrullination, one of the enzymatic posttranslational modifications has become a hot topic of recent research as it is involved in various physiological and pathological processes. Antibodies against citrullinated proteins called anti-citrullinated protein antibodies, are the hallmark (diagnostic and prognostic factors) of rheumatoid arthritis, and are specific for the disease. Citrullination has an important role in the normal function of the immune system, skin keratinization, the insulation of neurons and the plasticity of the central nervous system including its essential role in gene regulation. Abnormal citrullination has been proposed to play a role in multiple sclerosis and Alzheimer's disease, and recent research has drawn attention to its implication in tumorigenesis. Still, it is unclear whether citrullination is the cause or the consequence of these pathological alterations. Here, we discuss crucial aspects of citrullination during both physiological and pathological conditions. (C) 2012 Published by Elsevier Masson SAS on behalf of the Societe Francaise de Rhumatologie.
引用
收藏
页码:431 / 436
页数:6
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