P-TSA catalyzed facile and efficient synthesis of polyhydroquinoline derivatives through Hantzsch multi-component condensation

被引：127

作者：

Cherkupally, Sanjeeva Reddy ^{[1
]}

Mekala, Raghu ^{[1
]}

机构：

[1] Kakatiya Univ, Dept Chem, Warangal 506009, Andhra Pradesh, India

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 07期

关键词：

p-toluenesulfonic acid; polyhydroquinoline; one-pot conversion; multi-component condensation;

D O I：

10.1248/cpb.56.1002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A facile and efficient synthetic route to polyhydroquinolines has been developed via four-component condensation reactions of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of p-toluenesulfonic acid (p-TSA) catalyst in ethanol at ambient temperature through Hantzsch reaction. Simple work-up procedure, environmentally friendly, inexpensive and non-toxic catalyst, shorter reaction times along with excellent product yields are the significant features of this practical method.

引用

页码：1002 / 1004

页数：3

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