Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities

被引：146

作者：

Porru, Manuela ^{[1
]}

Pompili, Luca ^{[1
,2
]}

Caruso, Carla ^{[2
]}

Biroccio, Annamaria ^{[3
]}

Leonetti, Carlo ^{[1
]}

机构：

[1] Regina Elena Inst Canc Res, UOSD SAFU, Rome, Italy

[2] Univ Tuscia, Viterbo, Italy

[3] Regina Elena Inst Canc Res, Oncogenom & Epigenet Unit, Rome, Italy

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2018年 / 37卷

关键词：

QUADRUPLEX DNA STRUCTURES; MAPK PATHWAY ACTIVATION; PHASE-III TRIAL; ANTITUMOR-ACTIVITY; PRECLINICAL MODELS; PANCREATIC-CANCER; TUMOR-SUPPRESSOR; SMALL MOLECULES; RAS; INHIBITORS;

D O I：

10.1186/s13046-018-0719-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Developing drugs that target KRAS, the most frequently mutated oncogene in cancer, has not been successful despite much concerted efforts dedicated towards it in the last thirty years. Considering the key role this driver oncogene plays, the pharmacological drugging of KRAS remains a key challenge for cancer research. In this review, we highlight the emerging experimental strategies for blocking KRAS function and signaling and its direct targeting. We also report on the results in this field of research produced by our group.

引用

页数：10

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