Synthesis of 3-iodopyrrolocoumarins via iodine-induced 5-endo-dig electrophilic cyclization

被引：7

作者：

Majumdar, K. C. ^{[1
]}

De, Nirupam ^{[1
]}

Sinha, Biswajit ^{[1
]}

Roy, B. ^{[1
]}

机构：

[1] Univ Kalyani, Dept Chem, Kalyani 741235, W Bengal, India

来源：

MONATSHEFTE FUR CHEMIE | 2012年 / 143卷 / 07期

关键词：

Molecular iodine; Electrophilic cyclization; 3-Iodopyrrolocoumarins; 5-endo-dig Cyclization; LAMELLARIN-ALPHA; 20-SULFATE; PYRROLOCOUMARIN DERIVATIVES; BIOLOGICAL-ACTIVITY; MOLECULAR-IODINE; IODOCYCLIZATION; INHIBITOR; AGENTS;

D O I：

10.1007/s00706-011-0694-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of 3-iodopyrrolocoumarins has been achieved by a simple and straightforward strategy involving palladium-copper-catalyzed Sonogashira coupling followed by iodocyclization at ambient temperature using molecular iodine as the electrophilic source. In addition, functionalization at the 3-position of the iodocyclized product is performed via Sonogashira reaction.

引用

页码：1067 / 1073

页数：7

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