D-Dimer Assays in Diagnosis and Management of Thrombotic and Bleeding Disorders

被引：135

作者：

Bates, Shannon M. ^{[1
,2
]}

机构：

[1] McMaster Univ, Dept Med, Hamilton, ON, Canada

[2] Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, Canada

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2012年 / 38卷 / 07期

关键词：

D-dimer; venous thromboembolism; recurrence; anticoagulant duration; DEEP-VEIN THROMBOSIS; RECURRENT VENOUS THROMBOEMBOLISM; SUSPECTED PULMONARY-EMBOLISM; DISSEMINATED INTRAVASCULAR COAGULATION; PROTHROMBIN FRAGMENT 1+2; QUANTITATIVE D-DIMER; PLASMA D-DIMER; CLINICAL PROBABILITY; COMPRESSION ULTRASONOGRAPHY; INTERNATIONAL SOCIETY;

D O I：

10.1055/s-0032-1326782

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

D-dimer is a global indicator of coagulation activation and fibrinolysis and, therefore, an indirect marker of thrombotic activity. The utility of D-dimer measurement has been evaluated in several clinical situations including the exclusion of venous thromboembolism (VTE), prediction of future risk of VTE, and the diagnosis and monitoring of disseminated intravascular coagulation (DIC). Assay standardization remains problematic and clinicians need to be aware of variability in D-dimer assay performance and the characteristics of their institution's test when making clinical decisions. This article will review the available evidence for the utilization of D-dimer antigen measurement in the management of thrombotic and bleeding disorders.

引用

页码：673 / 682

页数：10

共 93 条

[1] D-dimer antigen: current concepts and future prospects [J].

Adam, Soheir S. ;

Key, Nigel S. ;

Greenberg, Charles S. .

BLOOD, 2009, 113 (13) :2878-2887

[2] Diagnostic value of D-dimer in patients with a moderate pretest probability of deep venous thrombosis [J].

Aguilar, C ;

Martinez, A ;

Del Rio, C ;

Vazquez, M ;

Rodriguez, FJ .

BRITISH JOURNAL OF HAEMATOLOGY, 2002, 118 (01) :275-277

[3] Combined D-dimer and clinical probability are useful for exclusion of recurrent deep venous thrombosis [J].

Aguilar, Carlos ;

del Villar, Valentin .

AMERICAN JOURNAL OF HEMATOLOGY, 2007, 82 (01) :41-44

[4] Use of spiral computed tomography contrast angiography and ultrasonography to exclude the diagnosis of pulmonary embolism in the Emergency Department [J].

Anderson, DR ;

Kovacs, MJ ;

Dennie, C ;

Kovacs, G ;

Stiell, I ;

Dreyer, I ;

McCarron, B ;

Pleasance, S ;

Burton, E ;

Cartier, Y ;

Wells, PS .

JOURNAL OF EMERGENCY MEDICINE, 2005, 29 (04) :399-404

[5] Combined use of clinical assessment and D-dimer to improve the management of patients presenting to the emergency department with suspected deep vein thrombosis - (the EDITED Study) [J].

Anderson, DR ;

Kovacs, MJ ;

Kovacs, G ;

Stiell, I ;

Mitchell, M ;

Khoury, V ;

Dryer, J ;

Ward, J ;

Wells, PS .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2003, 1 (04) :645-651

[6] Appropriateness of diagnostic strategies for evaluating suspected venous thromboembolism [J].

Arnason, Thomas ;

Wells, Philip S. ;

Forster, Alan J. .

THROMBOSIS AND HAEMOSTASIS, 2007, 97 (02) :195-201

[7] Prediction of venous thromboembolism in cancer patients [J].

Ay, Cihan ;

Dunkler, Daniela ;

Marosi, Christine ;

Chiriac, Alexandru-Laurentiu ;

Vormittag, Rainer ;

Simanek, Ralph ;

Quehenberger, Peter ;

Zielinski, Christoph ;

Pabinger, Ingrid .

BLOOD, 2010, 116 (24) :5377-5382

[8] D-Dimer and Prothrombin Fragment 1+2 Predict Venous Thromboembolism in Patients With Cancer: Results From the Vienna Cancer and Thrombosis Study [J].

Ay, Cihan ;

Vormittag, Rainer ;

Dunkler, Daniela ;

Simanek, Ralph ;

Chiriac, Alexandru-Laurentiu ;

Drach, Johannes ;

Quehenberger, Peter ;

Wagner, Oswald ;

Zielinski, Christoph ;

Pabinger, Ingrid .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (25) :4124-4129

[9] High risk of recurrent venous thromboembolism in men [J].

Baglin, T ;

Luddington, R ;

Brown, K ;

Baglin, C .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2004, 2 (12) :2152-2155

[10]

BALLEGEER V, 1987, THROMB HAEMOSTASIS, V58, P1030

← 1 2 3 4 5 6 7 8 9 10 →