Advances in anion transport and supramolecular medicinal chemistry

被引:172
作者
Davis, Jeffery T. [1 ]
Gale, Philip A. [2 ]
Quesada, Roberto [3 ]
机构
[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
[2] Univ Sydney, Sch Chem F11, Sydney, NSW 2006, Australia
[3] Univ Burgos, Dept Quim, Burgas 09001, Bulgaria
基金
澳大利亚研究理事会;
关键词
CHLORIDE TRANSPORT; ION CHANNELS; CYSTIC-FIBROSIS; CELL-DEATH; RECOGNITION; SQUARAMIDES; BINDING; DYSFUNCTION; RECEPTORS; APOPTOSIS;
D O I
10.1039/c9cs00662a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Advances in anion transport by synthetic supramolecular systems are discussed in this article. Developments in the design of discrete molecular carriers for anions and supramolecular anion channels are reviewed followed by an overview of the use of these systems in biological systems as putative treatments for diseases such as cystic fibrosis and cancer.
引用
收藏
页码:6056 / 6086
页数:31
相关论文
共 111 条
[21]   Transmembrane Fluoride Transport: Direct Measurement and Selectivity Studies [J].
Clarke, Harriet J. ;
Howe, Ethan N. W. ;
Wu, Xin ;
Sommer, Fabian ;
Yano, Masafumi ;
Light, Mark E. ;
Kubik, Stefan ;
Gale, Philip A. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (50) :16515-16522
[22]   Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium [J].
Coakley, RD ;
Grubb, BR ;
Paradiso, AM ;
Gatzy, JT ;
Johnson, LG ;
Kreda, SM ;
O'Neal, WK ;
Boucher, RC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) :16083-16088
[23]   Ionophore constructed from non-covalent assembly of a G-quadruplex and liponucleoside transports K+-ion across biological membranes [J].
Debnath, Manish ;
Chakraborty, Sandipan ;
Kumar, Y. Pavan ;
Chaudhuri, Ritapa ;
Jana, Biman ;
Dash, Jyotirmayee .
NATURE COMMUNICATIONS, 2020, 11 (01)
[24]   Anthracene Bisureas as Powerful and Accessible Anion Carriers [J].
Dias, Christopher M. ;
Valkenier, Hennie ;
Davis, Anthony P. .
CHEMISTRY-A EUROPEAN JOURNAL, 2018, 24 (23) :6262-6268
[25]   Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes [J].
Dias, Christopher M. ;
Li, Hongyu ;
Valkenier, Hennie ;
Karagiannidis, Louise E. ;
Gale, Philip A. ;
Sheppard, David N. ;
Davis, Anthony P. .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2018, 16 (07) :1083-1087
[26]   Cystic fibrosis [J].
Elborn, J. Stuart .
LANCET, 2016, 388 (10059) :2519-2531
[27]   Strong Antibacterial Properties of Anion Transporters: A Result of Depolarization and Weakening of the Bacterial Membrane [J].
Elie, Claude R. ;
David, Guillaume ;
Schmitzer, Andreea R. .
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (05) :2358-2366
[28]   Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis [J].
Fiore, Michele ;
Cossu, Claudia ;
Capurro, Valeria ;
Picco, Cristiana ;
Ludovico, Alessandra ;
Mielczarek, Marcin ;
Carreira-Barral, Israel ;
Caci, Emanuela ;
Baroni, Debora ;
Quesada, Roberto ;
Moran, Oscar .
BRITISH JOURNAL OF PHARMACOLOGY, 2019, 176 (11) :1764-1779
[29]   Versatile symport transporters based on cyclic peptide dimers [J].
Fuertes, Alberto ;
Amorin, Manuel ;
Granja, Juan R. .
CHEMICAL COMMUNICATIONS, 2020, 56 (01) :46-49
[30]   Anion transport and supramolecular medicinal chemistry [J].
Gale, Philip A. ;
Davis, Jeffery T. ;
Quesada, Roberto .
CHEMICAL SOCIETY REVIEWS, 2017, 46 (09) :2497-2519