Novel Approaches to the Diagnosis, Prevention, and Treatment of Medical Device-Associated Infections

被引：69

作者：

Vergidis, Paschalis ^{[1
]}

Patel, Robin ^{[1
,2
]}

机构：

[1] Mayo Clin, Div Clin Microbiol, Dept Lab Med & Pathol, Rochester, MN 55905 USA

[2] Mayo Clin, Div Infect Dis, Dept Internal Med, Rochester, MN 55905 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2012年 / 26卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Biofilm; Medical device; Catheter-associated urinary tract infection; Catheter-associated bloodstream infection; Orthopedic implant infection; Cardiovascular implantable electronic device infection; CENTRAL VENOUS CATHETERS; BLOOD-STREAM INFECTION; PROSTHETIC-JOINT INFECTION; STAPHYLOCOCCUS-AUREUS; DOUBLE-BLIND; SILVER-SULFADIAZINE; PSEUDOMONAS-AERUGINOSA; ANTIBIOTIC-PROPHYLAXIS; BACTERIAL-COLONIZATION; PULSED ULTRASOUND;

D O I：

10.1016/j.idc.2011.09.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pathogenesis of device-associated infections is related to biofilm bacteria that exhibit distinct characteristics with respect to growth rate, structural features, and protection from host immune mechanisms and antimicrobial agents when compared with planktonic counterparts. Biofilm-associated infections are prevented, diagnosed, and treated differently from infections not associated with biofilms. This article reviews innovative concepts for the prevention of biofilm formation, and novel treatment approaches. Specific approaches for the diagnosis and prevention of catheter-associated urinary tract and bloodstream infections, as well as infections associated with orthopedic implants and cardiovascular implantable electronic devices, are also discussed.

引用

页码：173 / +

页数：15

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