Locked nucleic acid molecular beacons

被引：179
作者：
Wang, L [1 ]
Yang, CYJ
Medley, CD
Benner, SA
Tan, WH
机构：
[1] Univ Florida, UF Genet Inst, Ctr Res Bio Nano Interface, Dept Chem, Gainesville, FL 32611 USA
[2] Univ Florida, McKnight Brain Inst, Shands Canc Ctr, Gainesville, FL 32611 USA
[3] Univ Florida, Dept Anat & Cell Biol, Gainesville, FL 32611 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 45期
关键词：
D O I：
10.1021/ja052498g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel LNA-MB (molecular beacon based on locked nucleic acid bases) has been designed and investigated. It exhibits very high melting temperature and is thermally stable, shows superior single base mismatch discrimination capability, and is stable against digestion by nuclease and has no binding with single-stranded DNA binding proteins. The LNA-MB will be widely useful in a variety of areas, especially for in vivo hybridization studies. Copyright © 2005 American Chemical Society.
引用
收藏
页码：15664 / 15665
页数：2
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