Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes

被引：136

作者：

Arslan, Hakan ^{[1
,2
]}

Duran, Nizami ^{[3
]}

Borekci, Gulay ^{[4
]}

Ozer, Cemal Koray ^{[2
]}

Akbay, Cevdet ^{[1
]}

机构：

[1] Fayetteville State Univ, Dept Nat Sci, Fayetteville, NC 28301 USA

[2] Mersin Univ, Fac Pharm, Dept Chem, TR-33169 Mersin, Turkey

[3] Mustafa Kemal Univ, Fac Med, Dept Microbiol, TR-31040 Antakya, Turkey

[4] Mersin Univ, Hlth Sch, TR-33169 Mersin, Turkey

来源：

MOLECULES | 2009年 / 14卷 / 01期

关键词：

Thiourea derivatives; Complexes; Antibacterial activity; Antifungal activity; In vitro studies; Lipophilicity; CRYSTAL-STRUCTURE; THERMAL-BEHAVIOR; MOLECULAR-STRUCTURE; METAL-COMPLEXES; CU(II); NI(II); COBALT(II); LIGANDS;

D O I：

10.3390/molecules14010519

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five thiourea derivative ligands and their Ni2+ and Cu2+ complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus) and Gram-negative bacteria (Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and in vitro anti-yeast activity (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed.

引用

页码：519 / 527

页数：9

共 29 条

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