Portable system for photodiode-based electrochemiluminescence measurement with improved limit of detection

被引：13

作者：

Carvajal, M. A. ^{[1
]}

Ballesta-Claver, J. ^{[2
]}

Martinez-Olmos, A. ^{[1
]}

Capitan-Vallvey, L. F. ^{[2
]}

Palma, A. J. ^{[1
]}

机构：

[1] Univ Granada, Dept Elect & Comp Technol, ECsens, CITIC UGR, E-18071 Granada, Spain

[2] Univ Granada, Dept Analyt Chem, ECsens, E-18071 Granada, Spain

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2015年 / 221卷

关键词：

Electrochemiluminescence; Portable instrument; Limit of detection; Programmable Gain Amplifier; ORGANIC PHOTODIODES; CHEMILUMINESCENCE; SENSOR;

D O I：

10.1016/j.snb.2015.07.038

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Several techniques to improve the limit of detection CLOD) of analytical systems for electrochemiluminescent (ECL) reactions are presented. This work focuses on ECL measurement based on photodiodes and techniques to improve it, which were implemented and tested in a portable instrument. Three different topologies of ECL measurement systems were compared. One system consisted of a photo-multiplier (PMT) with a photocounting device and a commercial potentiostat. The other two topologies used an ad hoc potentiostat and a photodiode with different conditioning electronics: one with Field Programmable Analog Arrays (FPAA) and the other using conventional analog electronics with a programmable gain amplifier (PGA). The three systems were tested using triethylamine (TEA) as the analyte and tris(2,2'bipyridyl)ruthenium(II) as the transduction chemistry. The detection limit achieved with the system with conventional electronics and PGA was 0.02 mg l(-1), nine times lower than the system with FPAA and 45 times lower than the commercial system with the photomultiplier (PMT). (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：956 / 961

页数：6

共 25 条

[1] Disposable electrochemiluminescent biosensor for lactate determination in saliva [J].

Ballesta Claver, J. ;

Valencia Miron, M. C. ;

Capitan-Vallvey, L. F. .

ANALYST, 2009, 134 (07) :1423-1432

[2]

Burle Technologies Inc., 1989, PHOT HDB

[3] Portable reconfigurable instrument for analytical determinations using disposable electrochemiluminescent screen-printed electrodes [J].

Carvajal, M. A. ;

Ballesta-Claver, J. ;

Morales, D. P. ;

Palma, A. J. ;

Valencia-Miron, M. C. ;

Capitan-Vallvey, L. F. .

SENSORS AND ACTUATORS B-CHEMICAL, 2012, 169 :46-53

[4] Comparison of homoleptic and heteroleptic 2,2′-bipyridine and 1,10-phenanthroline ruthenium complexes as chemiluminescence and electrochemiluminescence reagents in aqueous solution [J].

Cooke, Michaela M. ;

Doeven, Egan H. ;

Hogan, Conor F. ;

Adcock, Jacqui L. ;

McDermott, Geoffrey P. ;

Conlan, Xavier A. ;

Barnett, Neil W. ;

Pfeffer, Frederick M. ;

Francis, Paul S. .

ANALYTICA CHIMICA ACTA, 2009, 635 (01) :94-101

[5] Biocompatible electrochemiluminescent biosensor for choline based on enzyme/titanate nanotubes/chitosan composite modified electrode [J].

Dai, Hong ;

Chi, Yuwu ;

Wu, Xiaoping ;

Wang, Youmei ;

Wei, Mingdeng ;

Chen, Guonan .

BIOSENSORS & BIOELECTRONICS, 2010, 25 (06) :1414-1419

[6] Electrogenerated chemiluminescence of nanomaterials for bioanalysis [J].

Deng, Shengyuan ;

Ju, Huangxian .

ANALYST, 2013, 138 (01) :43-61

[7] Recent developments in handheld and portable optosensing-A review [J].

Fermin Capitan-Vallvey, Luis ;

Palma, Alberto J. .

ANALYTICA CHIMICA ACTA, 2011, 696 (1-2) :27-46

[8] ELECTRO-LUMINESCENCE OF THE ELECTROLYTE-N-ZNSE JUNCTION UNDER ANODIC POLARIZATION [J].

GAUTRON, J ;

DALBERA, JP ;

LEMASSON, P .

SURFACE SCIENCE, 1980, 99 (02) :300-308

[9] High-frequency electrochemiluminescent investigation of the reaction pathway between tris(2,2′-bipyridyl)ruthenium(II) and tripropylamine using carbon fiber microelectrodes [J].

Gross, EM ;

Pastore, P ;

Wightman, RM .

JOURNAL OF PHYSICAL CHEMISTRY B, 2001, 105 (37) :8732-8738

[10] DEVELOPMENT OF A CHEMILUMINESCENCE DETECTOR WITH PHOTODIODE DETECTION FOR FLOW-INJECTION ANALYSIS AND ITS APPLICATION TO L-LACTATE ANALYSIS [J].

HEMMI, A ;

YAGIUDA, K ;

FUNAZAKI, N ;

ITO, S ;

ASANO, Y ;

IMATO, T ;

HAYASHI, K ;

KARUBE, I .

ANALYTICA CHIMICA ACTA, 1995, 316 (03) :323-327

← 1 2 3 →