Caffeine Encapsulated in Small Unilamellar Liposomes: Characerization and In Vitro Release Profile

被引：36

作者：

Chorilli, Marlus ^{[1
]}

Calixto, Giovana ^{[1
]}

Rimerio, Thereana Cristina ^{[1
]}

Scarpa, Maria Virginia ^{[1
]}

机构：

[1] Sao Paulo State Univ, UNESP, Sch Pharmaceut Sci, BR-14801902 Sao Paulo, Brazil

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2013年 / 34卷 / 10期

基金：

巴西圣保罗研究基金会;

关键词：

Caffeine; hydrogenated soy phosphatidylcholine; in vitro drug release; liposomes; PERCUTANEOUS-ABSORPTION; HUMAN SKIN; PHOSPHATIDYLCHOLINE; DELIVERY; FORMULATIONS; PERMEATION; DICLOFENAC; PHOSPHOLIPIDS; DEGRADATION; CHOLESTEROL;

D O I：

10.1080/01932691.2012.739535

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Liposomes containing hydrogenated soy phosphatidylcholine (PCH), with or without cholesterol (CHOL) and caffeine (CAF), were prepared by sonication and characterized for encapsulation efficiency and mean diameter. Dynamic light scattering assay showed that the incorporation of CHOL decreased significantly the size of the liposomes and led to a more heterogeneous distribution of size raising the CAF encapsulation efficiency. The in vitro drug release studies showed that the encapsulation of the CAF in liposomes produced a reduction in the release rate and the inclusion of CHOL in the liposome formulation delayed still further the release of the CAF.

引用

页码：1465 / 1470

页数：6

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