Stereoselective copper-catalyzed Chan-Lam-Evans N-arylation of glucosamines with arylboronic acids at room temperature

被引：46

作者：

Bruneau, Alexandre ^{[1
]}

Brion, Jean-Daniel ^{[1
]}

Alami, Mouad ^{[1
]}

Messaoudi, Samir ^{[1
]}

机构：

[1] Univ Paris Sud, CNRS, BioCIS UMR 8076, Lab Chim Therapeut,LabEx LERMIT,Fac Pharm, F-92296 Chatenay Malabry, France

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 75期

关键词：

COUPLING REACTIONS; NITROGEN; ANALOGS; ACCESS; UNIT;

D O I：

10.1039/c3cc44780d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and practical N-arylation of glycosylamines with substituted aryl boronic acids has been established. Using Cu(OAc)(2) and pyridine at room temperature under air atmosphere, the protocol proved to be general, and a variety of aryl N-glycosides have been prepared in good to excellent yields with exclusive beta selectivity.

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收藏

页码：8359 / 8361

页数：3

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