Tumor-derived exosomes: Implication in angiogenesis and antiangiogenesis cancer therapy

被引：116

作者：

Aslan, Cynthia ^{[1
,2
]}

Maralbashi, Sepideh ^{[3
]}

Salari, Farhad ^{[3
]}

Kahroba, Houman ^{[4
]}

Sigaroodi, Faraz ^{[5
]}

Kazemi, Tohid ^{[6
]}

Kharaziha, Pedram ^{[7
]}

机构：

[1] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[3] Kermanshah Univ Med Sci, Student Res Comm, Kermanshah, Iran

[4] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Mol Med, Tabriz, Iran

[5] Tabriz Univ Med Sci, Dept Anat Sci, Fac Med, Tabriz, Iran

[6] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[7] Linkoping Univ Hosp, Dept Clin Genet, Linkoping, Sweden

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 10期

关键词：

angiogenesis; cancer therapy; exosomes; extracellular vesicles; tumor; CELLS PROMOTE ANGIOGENESIS; MESENCHYMAL STEM-CELLS; MULTIPLE-MYELOMA CELLS; MARROW STROMAL CELLS; EXTRACELLULAR VESICLES; GLIOMA-CELLS; INTERCELLULAR TRANSFER; ENDOTHELIAL-CELLS; LEUKEMIA-CELLS; DELIVERY;

D O I：

10.1002/jcp.28374

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tumor cells utilize different strategies to communicate with neighboring tissues for facilitating tumor progression and invasion, one of these strategies has been shown to be the release of exosomes. Exosomes are small nanovesicles secreted by all kind of cells in the body, especially cancer cells, and mediate cell to cell communications. Exosomes play an important role in cancer invasiveness by harboring various cargoes that could accelerate angiogenesis. Here first, we will present an overview of exosomes, their biology, and their function in the body. Then, we will focus on exosomes derived from tumor cells as tumor angiogenesis mediators with a particular emphasis on the underlying mechanisms in various cancer origins. Also, exosomes derived from stem cells and tumor-associated macrophages will be discussed in this regard. Finally, we will discuss the novel therapeutic strategies of exosomes as drug delivery vehicles against angiogenesis.

引用

页码：16885 / 16903

页数：19

共 132 条

[1] Intercellular transfer of the oncogenic receptor EGFrvIII by microvesicles derived from tumour cells [J].