A honeybee stinger-inspired self-interlocking microneedle patch and its application in myocardial infarction treatment

被引：37

作者：

Lu, Yuwen ^{[1
]}

Ren, Tanchen ^{[2
]}

Zhang, Hua ^{[3
]}

Jin, Qiao ^{[4
]}

Shen, Liyin ^{[1
]}

Shan, Mengqi ^{[5
]}

Zhao, Xinzhe ^{[6
]}

Chen, Qichao ^{[6
]}

Dai, Haoli ^{[1
]}

Yao, Lin ^{[7
]}

Xie, Jieqi ^{[1
]}

Ye, Di ^{[3
]}

Lin, Tengxiang ^{[7
]}

Hong, Xiaoqian ^{[2
]}

Deng, Kaicheng ^{[1
]}

Shen, Ting ^{[1
]}

Pan, Jiazhen ^{[3
]}

Jia, Mengyan ^{[3
]}

Ling, Jun ^{[1
]}

Li, Peng ^{[7
]}

Zhang, Yue ^{[8
]}

Wang, Huanan ^{[3
]}

Zhuang, Lenan ^{[4
,9
]}

Gao, Changyou ^{[1
]}

Mao, Jifu ^{[5
]}

Zhu, Yang ^{[1
,10
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Cardiol,Cardiovasc Key Lab Zhejiang Prov, Hangzhou 310009, Peoples R China

[3] Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Peoples R China

[4] Zhejiang Univ, Inst Genet & Reprod, Coll Anim Sci, Hangzhou, Peoples R China

[5] Donghua Univ, Coll Text, Shanghai 201620, Peoples R China

[6] Shanghai Banyun Med Tech Co Ltd, Shanghai 201203, Peoples R China

[7] Zhejiang Univ, Coll Opt Sci & Engn, State Key Lab Modern Opt Instrumentat, Hangzhou 310027, Peoples R China

[8] San Francisco VA Med Ctr, San Francisco, CA 94121 USA

[9] Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Cardiol,Key Lab Cardiovasc Intervent & Regene, Hangzhou, Peoples R China

[10] Zhejiang Univ, Binjiang Inst, Hangzhou 310053, Peoples R China

来源：

ACTA BIOMATERIALIA | 2022年 / 153卷

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

Microneedle patches; Myocardial infarction; Bioinspired materials; Minimally invasive surgeries;

D O I：

10.1016/j.actbio.2022.09.015

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Weak tissue adhesion remains a major challenge in clinical translation of microneedle patches. Mimicking the structural features of honeybee stingers, stiff polymeric microneedles with unidirectionally backward -facing barbs were fabricated and embedded into various elastomer films to produce self-interlocking mi-croneedle patches. The spirality of the barbing pattern was adjusted to increase interlocking efficiency. In addition, the micro-bleeding caused by microneedle puncturing adhered the porous surface of the patch substrate to the target tissue via coagulation. In the demonstrative application of myocardial infarction treatment, the bioinspired microneedle patches firmly fixed on challenging beating hearts, significantly reduced cardiac wall stress and strain in the infarct, and maintained left ventricular function and mor-phology. In addition, the microneedle patch was minimally invasively implanted onto beating porcine heart in 10 minutes, free of sutures and adhesives. Therefore, the honeybee stinger-inspired microneedles could provide an adaptive and convenient means to implant patches for various medical applications.Statement of significanceAdhesion between tissue and microneedle patches with smooth microneedles is usually weak. We in-troduce a novel barbing method of fabricating unidirectionally backward facing barbs with controllable spirality on the microneedles on microneedle patches. The microneedle patches self-interlock on me-chanically dynamic beating hearts, similar to honeybee stingers. The micro-bleeding and coagulation on the porous surface provide additional adhesion force. The microneedle patches attenuate left ventricular remodeling via mechanical support and are compatible with minimally invasive implantation.(c) 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：386 / 398

页数：13

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