Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

被引：103

作者：

Quistgaard, Esben M. ^{[1
]}

Low, Christian ^{[1
]}

Moberg, Per ^{[1
]}

Tresaugues, Lionel ^{[1
]}

Nordlund, Par ^{[1
,2
]}

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden

[2] Nanyang Technol Univ, Sch Biol Sci, Singapore 639798, Singapore

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2013年 / 20卷 / 06期

基金：

瑞典研究理事会; 新加坡国家研究基金会;

关键词：

CRYSTAL-STRUCTURE; MECHANISM; SEQUENCE; MODEL;

D O I：

10.1038/nsmb.2569

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we present two structures of the major facilitator (MFS) xylose transporter XylE from Escherichia coli in inward open and partially occluded inward open conformations. These structures provide key information about the transport cycle of XylE and the closely related human GLUT transporters. This is, to our knowledge, the first MFS transporter structure determined in more than one conformational state, which may establish XylE as an important MFS model protein.

引用

页码：766 / +

页数：4

共 17 条

[11] Phaser crystallographic software
McCoy, Airlie J.
Grosse-Kunstleve, Ralf W.
Adams, Paul D.
Winn, Martyn D.
Storoni, Laurent C.
Read, Randy J.
[J]. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2007, 40 : 658 - 674
[12] Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2
Newstead, Simon
Drew, David
Cameron, Alexander D.
Postis, Vincent L. G.
Xia, Xiaobing
Fowler, Philip W.
Ingram, Jean C.
Carpenter, Elisabeth P.
Sansom, Mark S. P.
McPherson, Michael J.
Baldwin, Stephen A.
Iwata, So
[J]. EMBO JOURNAL, 2011, 30 (02) : 417 - 426
[13] Alternating access mechanism in the POT family of oligopeptide transporters
Solcan, Nicolae
Kwok, Jane
Fowler, Philip W.
Cameron, Alexander D.
Drew, David
Iwata, So
Newstead, Simon
[J]. EMBO JOURNAL, 2012, 31 (16) : 3411 - 3421
[14] Toward the structural genomics of complexes:: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis
Strong, Michael
Sawaya, Michael R.
Wang, Shuishu
Phillips, Martin
Cascio, Duilio
Eisenberg, David
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (21) : 8060 - 8065
[15] Crystal structure of a bacterial homologue of glucose transporters GLUT1-4
Sun, Linfeng
Zeng, Xin
Yan, Chuangye
Sun, Xiuyun
Gong, Xinqi
Rao, Yu
Yan, Nieng
[J]. NATURE, 2012, 490 (7420) : 361 - +
[16] Jalview Version 2-a multiple sequence alignment editor and analysis workbench
Waterhouse, Andrew M.
Procter, James B.
Martin, David M. A.
Clamp, Michele
Barton, Geoffrey J.
[J]. BIOINFORMATICS, 2009, 25 (09) : 1189 - 1191
[17] Woestenenk Esmeralda A., 2004, Journal of Structural and Functional Genomics, V5, P217, DOI 10.1023/B:jsfg.0000031965.37625.0e

← 1 2 →