Kahweol inhibits adipogenesis of 3T3-L1 adipocytes through downregulation of PPAR

被引：12
|
作者：
Kim, Jin Soo [1 ]
Lee, Seul Gi [1 ]
Kang, Young Jin [2 ]
Kwon, Taeg Kyu [3 ]
Nam, Ju-Ock [1 ]
机构：
[1] Kyungpook Natl Univ, Dept Food Sci & Biotechnol, Daegu, South Korea
[2] Yeungnam Univ, Dept Pharmacol, Coll Med, Daegu, South Korea
[3] Keimyung Univ, Sch Med, Dept Immunol, Daegu, South Korea
来源：
NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 10期
关键词：
3T3-L1; adipocytes; anti-adipogenic; Coffea arabica; kahweol; PPAR; PATHWAY; EXPRESSION; CELLS; GAMMA; FAT;
D O I：
10.1080/14786419.2017.1326039
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Kahweol, a compound from Coffea arabica, possesses antioxidant, anti-inflammatory, and antitumour properties. However, an anti-adipogenic effect has not yet been reported. In this study, we have shown that kahweol has an anti-adipogenic effect on 3T3-L1 adipocytes. Kahweol significantly inhibited the differentiation of intracellular lipid accumulation in 3T3-L1 adipocytes, without being cytotoxic. It also downregulated the expression of adipogenesis-related gene, including an adipocytokine, adiponectin. This anti-adipogenic effect stems from an ability to inhibit key adipogenic regulators, including PPAR and C/EBP. These results demonstrate that kahweol significantly inhibits the differentiation of 3T3-L1 cells, and suggest that it has potential as a novel anti-obesity treatment. [GRAPHICS] .
引用
收藏
页码：1216 / 1219
页数：4
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