The role of FSH and TGF-ß superfamily in follicle atresia

被引：79
作者：
Chu, Yu-Lan [1 ]
Xu, Ya-Ru [1 ]
Yang, Wan-Xi [1 ]
Sun, Yi [1 ]
机构：
[1] Zhejiang Univ, Coll Life Sci, Hangzhou 310058, Zhejiang, Peoples R China
来源：
AGING-US | 2018年 / 10卷 / 03期
关键词：
follicle atresia; apoptosis; ovary; FSH; TGF-ss; GRANULOSA-CELL APOPTOSIS; GROWTH-DIFFERENTIATION FACTOR-9; BONE MORPHOGENETIC PROTEIN-15; HISTONE H3 PHOSPHORYLATION; MESSENGER-RIBONUCLEIC-ACID; RNAI-MEDIATED KNOCKDOWN; STIMULATING-HORMONE; OVARIAN-FOLLICLES; ANTRAL FOLLICLES; KIT-LIGAND;
D O I：
10.18632/aging.101391
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Most of the mammalian follicles undergo a degenerative process called "follicle atresia". Apoptosis of granulosa cells is the main characteristic of follicle atresia. Follicle stimulating hormone (FSH) and the transforming growth factor ss (TGF-ss) superfamily have important regulatory functions in this process. FSH activates protein kinase A and cooperating with insulin receptor substrates, it promotes the PI3K/Akt pathway which weakens apoptosis. Both Smad or non-Smad signaling of the transforming growth factor ss superfamily seem to be related to follicle atresia, and the effect of several important family members on follicle atresia is concluded in this article. FSH and TGF-ss are likely to mutually influence each other and what we have already known about the possible underlying molecular mechanism is also discussed below.
引用
收藏
页码：305 / 321
页数：17
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