Pectin: A Long-Neglected Broad-Spectrum Antibacterial

被引:71
作者
Ciriminna, Rosaria [1 ]
Fidalgo, Alexandra [2 ,3 ]
Meneguzzo, Francesco [4 ]
Presentato, Alessandro [5 ]
Scurria, Antonino [1 ]
Nuzzo, Domenico [6 ]
Alduina, Rosa [5 ]
Ilharco, Laura M. [2 ,3 ]
Pagliaro, Mario [1 ]
机构
[1] CNR, Ist Studio Mat Nanostrutturati, Via U La Malfa 153, I-90146 Palermo, Italy
[2] Univ Lisbon, Inst Super Tecn, Ctr Quim Fis Mol, Av Rovisco Pais 1, P-1049001 Lisbon, Portugal
[3] Univ Lisbon, Inst Super Tecn, IN Inst Nanosci & Nanotechnol, Av Rovisco Pais 1, P-1049001 Lisbon, Portugal
[4] Ist Bioecon, Via Madonna Piano 10, I-50019 Sesto Fiorentino, Italy
[5] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, I-90028 Palermo, Italy
[6] CNR, Ist Ric & Innovaz Biomed, Via U La Malfa 153, I-90146 Palermo, Italy
关键词
antibacterial agents; antimicrobial agents; citrus pectin; pectin; polysaccharides; ANTIMICROBIAL ACTION; CITRUS PECTIN; EXTRACTION; ORANGE; AGENT;
D O I
10.1002/cmdc.202000518
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
First reported in the late 1930s and partly explained in 1970, the antibacterial activity of pectin remained almost ignored until the late 1990s. The concomitant emergence of research on natural antibacterials and new usages of pectin polysaccharides, including those in medicine widely researched in Russia, has led to a renaissance of research into the physiological properties of this uniquely versatile polysaccharide ubiquitous in plants and fruits. By collecting scattered information, this study provides an updated overview of the subtle factors affecting the behaviour of pectin as an antimicrobial. Less-degraded pectin extracted by acid-free routes, we argue in the conclusions, will soon find applications from new treatments for polymicrobial infections to use as an implantable biomaterial in tissue and bone engineering.
引用
收藏
页码:2228 / 2235
页数:8
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