Association between alpha-thalassaemia trait, Plasmodium falciparum asexual parasites and gametocyte carriage in a malaria endemic area in Southern Ghana

被引：3

作者：

Lamptey, Helena ^{[1
]}

Ofori, Michael Fokuo ^{[1
]}

Adu, Bright ^{[1
]}

Kusi, Kwadwo Asamoah ^{[1
]}

Dickson, Emmanuel Kakra ^{[1
]}

Quakyi, Isabella ^{[2
]}

Alifrangis, Michael ^{[3
,4
]}

机构：

[1] Univ Ghana, Dept Immunol, Noguchi Mem Inst Med Res, Coll Hlth Sci, Legon, Ghana

[2] Univ Ghana, Dept Biol Environm & Occupat Hlth Sci, Coll Hlth Sci, Sch Publ Hlth, Legon, Ghana

[3] Univ Copenhagen, Dept Immunol & Microbiol, Ctr Med Parasitol, Copenhagen, Denmark

[4] Rigshosp, Natl Univ Hosp, Dept Infect Disg, Copenhagen, Denmark

来源：

BMC RESEARCH NOTES | 2019年 / 12卷 / 1期

关键词：

Alpha-thalassaemia; Gametocyte carriage; Plasmodium falciparum; Submicroscopic parasites;

D O I：

10.1186/s13104-019-4181-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective: The alpha-thalassaemia trait has been associated with protection against severe malaria but its role in Plasmodium falciparum asexual parasite and gametocyte carriage remains unclear. This study examined association between prevalence of alpha-thalassaemia and P. falciparum asexual stage parasitaemia and gametocytaemia in children, pregnant women and adults, which was part of a bigger study that investigated some key factors that influence gametocyte carriage. Results: Overall prevalence of heterozygous alpha-thalassaemia trait among all the groups was 39.0%, while 8.2% were homozygous alpha thalassaemia. Asexual parasite prevalence was significantly higher in children (P = 0.008) compared to adults and pregnant women. Of the asexual P. falciparum positive individuals, gametocyte prevalence was 38.5% (15/39) in children, 29.7% (11/37) in pregnant women and 17.4% (4/23) in adults. Heterozygous alpha-thalassaemic children were less likely to harbour asexual parasites, compared with normal and those deficient (OR = 0.52; 95% CI 0.28-0.97; P = 0.037) under the dominant model. These heterozygous children were also associated with reduced risk of parasitaemia compared to heterozygous adults and pregnant women. Children with heterozygous alpha-thalassaemia trait had reduced risk of asexual parasite carriage. There was however, no association between alpha-thalassaemia trait and risk of gametocyte carriage.

引用

页数：5

共 25 条

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