Protein unfolding - Trapped in the act

被引：5

作者：

Baker, TA

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

来源：

NATURE | 1999年 / 401卷 / 6748期

关键词：

D O I：

10.1038/43341

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When a protein has been selected for destruction it is usually tagged with a specific destruction signal then it is thought to be unfolded and fed into the protein-digesting machinery. Such global unfolding is now demonstrated directly for the first time, in the ClpAP bacterial protein-destruction system, through the clever use of a green fluorescent protein as the target.

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页码：29 / 30

页数：2

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