共 48 条
Aversive Event Anticipation Affects Connectivity between the Ventral Striatum and the Orbitofrontal Cortex in an fMRI Avoidance Task
被引:17
作者:
Bolstad, Ingeborg
[1
,2
]
Andreassen, Ole A.
[1
,2
]
Reckless, Greg E.
[1
,2
]
Sigvartsen, Niels P.
[1
]
Server, Andres
[3
]
Jensen, Jimmy
[1
,2
,4
]
机构:
[1] Oslo Univ Hosp, Div Mental Hlth & Addict, KG Jebsen Ctr Psychosis Res, Oslo, Norway
[2] Univ Oslo, Inst Clin Med, Oslo, Norway
[3] Oslo Univ Hosp, Dept Neuroradiol, Oslo, Norway
[4] Kristianstad Univ, Ctr Psychol, Kristianstad, Sweden
来源:
关键词:
FUNCTIONAL NEUROANATOMY;
NUCLEUS-ACCUMBENS;
COGNITIVE CONTROL;
HUMAN AMYGDALA;
REWARD;
ACTIVATION;
SALIENCE;
DOPAMINE;
VALENCE;
SYSTEM;
D O I:
10.1371/journal.pone.0068494
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Ability to anticipate aversive events is important for avoiding dangerous or unpleasant situations. The motivation to avoid an event is influenced by the incentive salience of an event-predicting cue. In an avoidance fMRI task we used tone intensities to manipulate salience in order to study the involvement of the orbitofrontal cortex in processing of incentive salience. In the task, cues predicting either aversive or neutral avoidable tones were presented. Ventral striatum, amygdala and anterior insula activations were significantly stronger during presentation of cues for aversive than neutral tones. A psychophysiological interaction analysis showed stronger connectivity between the ventral striatum and the orbitofrontal cortex during aversive than neutral conditions. The present study shows an interaction between the ventral striatum, a structure previously linked to negative incentive salience, and the orbitofrontal cortex supporting a role for this region in processing salience. In addition, this study replicates previous findings suggesting that the task is robust.
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页数:8
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