Purification, in vitro antioxidant and in vivo anti-aging activities of soluble polysaccharides by enzyme-assisted extraction from Agaricus bisporus

被引：49

作者：

Li, Shangshang ^{[1
]}

Liu, Min ^{[1
]}

Zhang, Chen ^{[1
]}

Tian, Chengye ^{[2
]}

Wang, Xiuxiu ^{[1
]}

Song, Xinling ^{[1
]}

Jing, Huijuan ^{[1
]}

Gao, Zheng ^{[1
]}

Ren, Zhenzhen ^{[1
]}

Liu, Weiru ^{[3
]}

Zhang, Jianjun ^{[1
]}

Jia, Le ^{[1
]}

机构：

[1] Shandong Agr Univ, Coll Life Sci, Tai An 271018, Shandong, Peoples R China

[2] Comprehens Supervis & Enforcement Bur Sanitat & F, Tai An 271000, Shandong, Peoples R China

[3] Second High Sch Taian, Tai An 271018, Shandong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 109卷

关键词：

Agaricus bisporus; Polysaccharides; Enzyme-assisted extraction; Purification; Antioxidant activities; Anti-aging activities; AMELIORATES COGNITION DEFICITS; INTRACELLULAR POLYSACCHARIDE; OXIDATIVE STRESS; PROTEIN; OPTIMIZATION;

D O I：

10.1016/j.ijbiomac.2017.12.108

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In present study, the soluble polysaccharides by enzyme-assisted extraction from Agaricus bisporus (EnAPS) and its purified fractions of EnAPS-1. -2 and -3 were successfully obtained, and the antioxidant activities and anti-aging effects were investigated. The in vitro antioxidant assay demonstrated that EnAPS-2 had superior scavenging activities on DPPH and hydroxyl radicals, chelating activities of Fe2+ and reducing power. The in vivo animal experiments showed that both EnAPS and its purifies fractions had potential anti-aging effects against the D-galctose-induced aging diseases on liver, kidney, brain and skin, possibly by increasing the antioxidant enzymes, reducing the lipid peroxidation, improving the organ functions and remitting the lipid metabolism. The conclusions demonstrated that the polysaccharides by A. bisporus might be suitable for applying functional foods and natural drugs in preventing and delaying the aging and its complications. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：457 / 466

页数：10

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