Exposure to Organophosphate Pesticides and Menstrual Cycle Characteristics in Chinese Preconceptional Women

被引:15
作者
Zhang, Yan [1 ]
Ji, Lin [1 ]
Hu, Yi [1 ,2 ]
Tse, Lap Ah [3 ]
Wang, Yiwen [4 ,5 ]
Qin, Kaili [1 ]
Ding, Guodong [4 ,6 ]
Zhou, Yijun [1 ]
Yu, Xiaodan [7 ]
Ouyang, Fengxiu [4 ]
Zhang, Jun [4 ]
Gao, Yu [1 ]
Tian, Ying [1 ,4 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Publ Hlth, Dept Environm Hlth, Sch Med, 280 South Chongqing Rd, Shanghai 200025, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Ctr Med Bioinformat, Shanghai, Peoples R China
[3] Chinese Univ Hong Kong, JC Sch Publ Hlth & Primary Care, Div Occupat & Environm Hlth, Hong Kong, Peoples R China
[4] Shanghai Jiao Tong Univ, MOE Shanghai Key Lab Childrens Environm Hlth, Xinhua Hosp, Sch Med, Shanghai, Peoples R China
[5] Shanghai Jiao Tong Univ, Sch Med, Dept Neonatol, Xinhua Hosp, Shanghai, Peoples R China
[6] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Dept Resp Med, Shanghai, Peoples R China
[7] Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Dev & Behav Pediat, Sch Med, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
China; menstruation; organophosphates; pesticides; preconception; women; CHLORPYRIFOS; PREGNANCY; INSECTICIDES; VARIABILITY; MATURATION; TOXICITY; LENGTH; COHORT; GLAND; TIME;
D O I
10.1093/aje/kwz242
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Organophosphates (OPs) are the most heavily used pesticides in China. The Chinese population, including preconceptional women, is highly exposed, yet little is known regarding the associations between OP exposure and menstruation in humans. We conducted a cross-sectional analysis in women preparing for pregnancy to investigate the relationship between biomarkers of OP exposure and menstrual cycle characteristics. From 2013 to 2015, 627 women visiting free preconception-care clinics at 2 maternity hospitals in Shanghai, China, were included. Information on menstrual cycle characteristics was obtained through questionnaires. OP exposure was assessed by measuring urine concentrations of 6 dialkylphosphate metabolites (dimethylphosphate, dimethylthiophosphate, dimethyldithiophosphate, diethylphosphate, diethylthiophosphate, and diethyldithiophosphate). The relationship between concentrations of dialkylphosphate metabolites and menstrual cycle characteristics was analyzed using multiple linear regression models and logistic regression models. Log-transformed levels of diethyl phosphate metabolites (the sum of diethylphosphate and diethylthiophosphate levels) were related to a higher risk of irregularity of menstrual cycles (adjusted odds ratio = 2.36, 95% confidence interval: 1.28, 4.34). Subjects with a higher concentration of diethyl phosphate metabolites (log-transformed) had a shorter duration of menstrual bleeding (adjusted beta = -0.33, 95% confidence interval: -0.64, -0.02). The findings suggest that OP exposure may be associated with alterations in menstrual function in preconceptional women.
引用
收藏
页码:375 / 383
页数:9
相关论文
共 53 条
  • [1] Akhtar N, 1996, J APPL TOXICOL, V16, P397, DOI 10.1002/(SICI)1099-1263(199609)16:5<397::AID-JAT362>3.0.CO
  • [2] 2-Y
  • [3] [Anonymous], 2008, WORLD PESTIC, DOI DOI 10.3969/J.ISSN.1009-6485.2008.06.005
  • [4] Asmathbanu I., 1997, Journal of Basic and Clinical Physiology and Pharmacology, V8, P237
  • [5] Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the US population
    Barr, DB
    Bravo, R
    Weerasekera, G
    Caltabiano, LM
    Whitehead, RD
    Olsson, AO
    Caudill, SA
    Schober, SE
    Pirkle, JL
    Sampson, EJ
    Jackson, RJ
    Needham, LL
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2004, 112 (02) : 186 - 200
  • [6] Effects of the insecticides malathion and diazinon on the early oogenesis in mice in vitro
    Bonilla, Edmundo
    Hernandez, Fidel
    Cortes, Leticia
    Mendoza, Miriam
    Mejia, Joel
    Carrillo, Edgar
    Casas, Eduardo
    Betancourt, Miguel
    [J]. ENVIRONMENTAL TOXICOLOGY, 2008, 23 (02) : 240 - 245
  • [7] Organophosphate urinary metabolite levels during pregnancy and after delivery in women living in an agricultural community
    Bradman, A
    Eskenazi, B
    Barr, DB
    Bravo, R
    Castorina, R
    Chevrier, J
    Kogut, K
    Harnly, ME
    McKone, TE
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2005, 113 (12) : 1802 - 1807
  • [8] Modeled estimates of chlorpyrifos exposure and dose for the Minnesota and Arizona NHEXAS populations
    Buck, RJ
    Özkaynak, H
    Xue, JP
    Zartarian, VG
    Hammerstrom, K
    [J]. JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY, 2001, 11 (03): : 253 - 268
  • [9] DDT serum concentration and menstruation among young Chinese women
    Chen, AM
    Zhang, J
    Zhou, LF
    Gao, ES
    Chen, L
    Rogan, WJ
    Wolff, MS
    [J]. ENVIRONMENTAL RESEARCH, 2005, 99 (03) : 397 - 402
  • [10] Chia SE, 1997, AM J IND MED, V31, P148