Drug-induced Immune Thrombocytopenia

被引：24

作者：

Chong, Beng H. ^{[1
,2
]}

Choi, Philip Young-Ill ^{[2
,3
]}

Khachigian, Levon ^{[3
]}

Perdomo, Jose ^{[2
,3
]}

机构：

[1] St George Hosp, Dept Haematol, Kogarah, NSW 2217, Australia

[2] Univ New S Wales, St George Hosp, Dept Med, St George Clin Sch, Kogarah, NSW 2217, Australia

[3] Univ New S Wales, Ctr Vasc Res, Sydney, NSW 2033, Australia

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2013年 / 27卷 / 03期

关键词：

Drugs; Thrombocytopenia; Immune; Antibodies; QUININE-INDUCED THROMBOCYTOPENIA; HEPARIN-INDUCED THROMBOCYTOPENIA; PLATELET GLYCOPROTEIN IIB/IIIA; DEPENDENT ANTIBODIES; PROFOUND THROMBOCYTOPENIA; IN-VITRO; ANTIPLATELET ANTIBODIES; NONCYTOTOXIC DRUGS; NOD/SCID MOUSE; BINDING-SITE;

D O I：

10.1016/j.hoc.2013.02.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thrombocytopenia is caused by immune reactions elicited by diverse drugs in clinical practice. The activity of the drug-dependent antibodies produces a marked decrease in blood platelets and a risk of serious bleeding. Understanding of the cellular mechanisms that drive drug-induced thrombocytopenia has advanced recently but there is still a need for improved laboratory tests and treatment options. This article provides an overview of the different types of drug-induced thrombocytopenia, discusses potential pathologic mechanisms, and considers diagnostic methods and treatment options.

引用

页码：521 / +

页数：21

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