Drug-induced Immune Thrombocytopenia

被引：24
|
作者：
Chong, Beng H. [1 ,2 ]
Choi, Philip Young-Ill [2 ,3 ]
Khachigian, Levon [3 ]
Perdomo, Jose [2 ,3 ]
机构：
[1] St George Hosp, Dept Haematol, Kogarah, NSW 2217, Australia
[2] Univ New S Wales, St George Hosp, Dept Med, St George Clin Sch, Kogarah, NSW 2217, Australia
[3] Univ New S Wales, Ctr Vasc Res, Sydney, NSW 2033, Australia
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2013年 / 27卷 / 03期
关键词：
Drugs; Thrombocytopenia; Immune; Antibodies; QUININE-INDUCED THROMBOCYTOPENIA; HEPARIN-INDUCED THROMBOCYTOPENIA; PLATELET GLYCOPROTEIN IIB/IIIA; DEPENDENT ANTIBODIES; PROFOUND THROMBOCYTOPENIA; IN-VITRO; ANTIPLATELET ANTIBODIES; NONCYTOTOXIC DRUGS; NOD/SCID MOUSE; BINDING-SITE;
D O I：
10.1016/j.hoc.2013.02.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Thrombocytopenia is caused by immune reactions elicited by diverse drugs in clinical practice. The activity of the drug-dependent antibodies produces a marked decrease in blood platelets and a risk of serious bleeding. Understanding of the cellular mechanisms that drive drug-induced thrombocytopenia has advanced recently but there is still a need for improved laboratory tests and treatment options. This article provides an overview of the different types of drug-induced thrombocytopenia, discusses potential pathologic mechanisms, and considers diagnostic methods and treatment options.
引用
收藏
页码：521 / +
页数：21
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