A Convergent Total Synthesis of 19-Hydroxysarmentogenin

被引：57

作者：

Mukai, Ken ^{[1
]}

Urabe, Daisuke ^{[1
]}

Kasuya, Satoshi ^{[1
]}

Aoki, Naoto ^{[1
]}

Inoue, Masayuki ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 20期

关键词：

aldol reaction; convergent strategy; radical reactions; steroids; total synthesis; RADICAL CYCLIZATION; STEROIDS; CARDENOLIDES; RING; CONSTRUCTION; OUABAGENIN; SYSTEM; PLANT;

D O I：

10.1002/anie.201302067

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

19 in 19: A convergent total synthesis of 19-hydroxysarmentogenin has been achieved, starting from three simple fragments. The desired product was synthesized in 19 steps from the AB ring system with the installation of six stereocenters and the formation of three C-C bonds. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5300 / 5304

页数：5

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