Triterpenoid Saponins with Anti-Inflammatory Activity from Codonopsis lanceolata

被引：51
|
作者：
Xu, Li-Ping
Wang, Hao [2 ]
Yuan, Zhong [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Dept Anal Tradit Chinese Med, Shenyang 110016, Peoples R China
[2] Jilin Univ, Clin Hosp 1, Changchun 130023, Peoples R China
来源：
PLANTA MEDICA | 2008年 / 74卷 / 11期
关键词：
Codonopsis lanceolata Benth. et Hook; Campanulaceae; triterpenoid saponins; anti-inflammatory activity;
D O I：
10.1055/s-2008-1081318
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Six triterpenoid saponins, including a new compound named codonolaside 111, were isolated from the roots of Codonopsis lanceolata. The spectral and chemical data revealed the structure of coclonolaside III to be 3-O-[beta-D-xylopyranosyl-(1 -> 3)-beta-D-glucuronopyranosyl]-3 beta,16 alpha-dihydroxyolean-12-ene-28-oic acid 28-O-[beta-D-xylopyranosyl-(1 -> 4)-alpha-L-rhamnpyranosyl-(1 -> 2)][beta-D-glucopyranosyl -(1 -> 4)]-alpha-L-arabinopyranosyl ester. The xylene-induced mouse ear edema inhibitory effect assay disclosed coclonolaside and codonolasides I - III as the major anti-inflammatory constituents in this crude drug.
引用
收藏
页码：1412 / 1415
页数：4
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