Formation of hyaluronic acid-ellagic acid microfiber hybrid hydrogels and their applications

被引：2

作者：

Barnaby, Stacey N. ^{[1
]}

Nakatsuka, Nako ^{[1
]}

Frayne, Stephen H. ^{[1
]}

Fath, Karl R. ^{[2
,3
]}

Banerjee, Ipsita A. ^{[1
]}

机构：

[1] Fordham Univ, Dept Chem, Bronx, NY 10458 USA

[2] CUNY, Dept Biol, Flushing, NY 11367 USA

[3] CUNY Queens Coll, Grad Ctr, Flushing, NY 11367 USA

来源：

COLLOID AND POLYMER SCIENCE | 2013年 / 291卷 / 03期

关键词：

Hydrogel; Microfibers; Assemblies; Hybrids; Biocompatible; CARBON NANOTUBES; IONIZABLE GROUPS; CRYSTAL VIOLET; PK VALUES; IN-VITRO; DELIVERY; BIOMATERIALS; CONJUGATION; CHITOSAN; COMPLEX;

D O I：

10.1007/s00396-012-2739-2

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Microfiber assemblies prepared from ellagic acid (EA) were functionalized with histidine (His) and dispersed in hyaluronic acid (HA) hydrogel microstructures. Swelling studies indicated that the hybrids had a relatively lower water uptake compared to HA and was pH dependent. The percentage swelling ratio for EA-His-HA hybrids was 48 % when 0.04 mg/mL of HA was incorporated and increased to 70 % when 1.2 mg/mL HA was integrated. Release studies using the dye crystal violet (CV) as a model drug showed that the rates were concentration-dependent. Further the hybrids were found to be thermally stable compared to HA. Cellular toxicity assays performed with normal rat kidney (NRK) cells indicated biocompatibility and adherence of the hybrids to the cells. Thus, we have developed a new family of hybrid hydrogels which readily formed on the EA-His functionalized microfibers and may have potential applications in drug delivery or tissue regeneration applications.

引用

页码：515 / 525

页数：11

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