Formulation study of directly compressible chewable polymers containing ascorbic acid

被引：4

作者：

Kasa, P. ^{[1
]}

Jojart, I. ^{[1
]}

Kelemen, A. ^{[2
]}

Pintye-Hodi, K. ^{[1
]}

机构：

[1] Univ Szeged, Dept Pharmaceut Technol, H-6720 Szeged, Hungary

[2] Univ Szeged, Dept Appl Informat, H-6720 Szeged, Hungary

来源：

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2013年 / 18卷 / 02期

关键词：

Chewing gum; direct compression; deformation; dissolution; Pharmagum; ascorbic acid; DRUG-DELIVERY SYSTEM; CHEWING GUM; APPARATUS;

D O I：

10.3109/10837450.2011.646426

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The topic of this article is the compression physics of different gum bases which can be used to prepare chewing gum tablets by direct compression. Three different gum bases, Pharmagum (R) C, M and S, were tested alone and in different combinations. The preparations were compressed with a Korsch EK0 eccentric tableting machine at compression forces of 5, 7.5, 10, 12.5 and 15 kN. The compression and breaking processes and the physical parameters of the tablets were investigated. The results revealed that increase of the compression force did not significantly change the studied parameters of the tablets.

引用

页码：384 / 389

页数：6

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