MicroRNAs and Atherosclerosis

被引：127
作者：
Madrigal-Matute, Julio [1 ,2 ,3 ]
Rotllan, Noemi [1 ,2 ,3 ]
Aranda, Juan F. [1 ,2 ,3 ]
Fernandez-Hernando, Carlos [1 ,2 ,3 ]
机构：
[1] NYU, Sch Med, Dept Med, Leon H Charney Div Cardiol, New York, NY 10016 USA
[2] NYU, Sch Med, Marc & Ruti Bell Vasc Biol & Dis Program, New York, NY 10016 USA
[3] NYU, Sch Med, Dept Cell Biol, Leon H Charney Div Cardiol, New York, NY 10016 USA
来源：
CURRENT ATHEROSCLEROSIS REPORTS | 2013年 / 15卷 / 05期
基金：
美国国家卫生研究院;
关键词：
MicroRNA; Atherosclerosis; Anti-miRNA therapy; miR-33; REVERSE CHOLESTEROL TRANSPORT; TARGET MESSENGER-RNAS; CIRCULATING MICRORNAS; IN-VIVO; ENDOTHELIAL-CELL; INFLAMMATORY RESPONSE; TANGIER-DISEASE; LIPID UPTAKE; AMINO-ACID; EXPRESSION;
D O I：
10.1007/s11883-013-0322-z
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
MicroRNAs (miRNAs) are small, similar to 22 nucleotide (nt) sequences of RNA that regulate gene expression at posttranscriptional level. These endogenous gene expression inhibitors were primarily described in cancer but recent exciting findings have also demonstrated a key role in cardiovascular diseases (CVDs), including atherosclerosis. MiRNAs control endothelial cell (EC), vascular smooth muscle cell (VSMC), and macrophage functions, and thereby regulate the progression of atherosclerosis. MiRNA expression is modulated by different stimuli involved in every stage of atherosclerosis, and conversely miRNAs modulates several pathways implicated in plaque development such as cholesterol metabolism. In the present review, we focus on the importance of miRNAs in atherosclerosis, and we further discuss their potential use as biomarkers and therapeutic targets in CVDs.
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页数：8
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