Chemoresistance Is Associated with MUC1 and Lewis y Antigen Expression in Ovarian Epithelial Cancers

被引：17

作者：

Zhang, Danye ^{[1
]}

Gao, Jian ^{[1
]}

Zhu, Liancheng ^{[1
]}

Hu, Zhenhua ^{[1
]}

Hou, Rui ^{[1
]}

Liu, Shuice ^{[1
]}

Tan, Mingzi ^{[1
]}

Liu, Juanjuan ^{[1
]}

Lin, Bei ^{[1
]}

机构：

[1] China Med Univ, Dept Obstet & Gynecol, Shengjing Hosp, Shenyang 110004, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 06期

基金：

中国国家自然科学基金;

关键词：

ovarian epithelial cancer; MUC1; Lewis y antigen; chemoresistance; immunohistochemistry; APOPTOTIC RESPONSE; BREAST-CANCER; ONCOPROTEIN; RESISTANCE; CARCINOMA; CELLS; ADHESION; GENE; CHEMOTHERAPY; METASTASIS;

D O I：

10.3390/ijms140611024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Objective: The aim of this study was to analyze the correlation and clinical significance between the expression of Mucin-1 (MUC1) and the Lewis y antigen with chemoresistance in ovarian epithelial cancers. Methods: Ovarian cancer patients (n = 92) treated at our hospital from May 2005 to July 2009 were divided, according to their treatment and follow-up outcomes, into a resistant group (n = 37) or sensitive group (n = 55). The expression of MUC1 and Lewis y antigen in ovarian cancer tissues was detected using immunohistochemistry and correlated with chemoresistance. Results: The positive rates of MUC1 and Lewis y antigen in the resistant group were both 91.89%, significantly higher than their positive rates in the sensitive group (65.45% and 69.09%, respectively, and both p < 0.05). MUC1 or Lewis y expression and the pathological stage of the tissue were independent risk factors for chemoresistance (all p < 0.05). Conclusion: The increased expression of MUC1 and the Lewis y antigen is a significant risk factor for chemoresistance in patients with ovarian epithelial cancer.

引用

页码：11024 / 11033

页数：10

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