Metal release from hip prostheses: cobalt and chromium toxicity and the role of the clinical laboratory

被引:43
作者
Campbell, Jonathon R. [1 ]
Estey, Mathew P. [1 ]
机构
[1] Univ Hlth Network, Lab Med Program, Toronto, ON, Canada
关键词
chromium; cobalt; hip prosthesis; metal-on-metal; metal toxicity; OPTIC ATROPHY; WHOLE-BLOOD; RESURFACING ARTHROPLASTY; ADVERSE-REACTION; ION LEVELS; FAILURE; REPLACEMENT; ORIENTATION; SPECIFICITY; SENSITIVITY;
D O I
10.1515/cclm-2012-0492
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Individuals with advanced hip disease suffer from pain, impaired hip function, and decreased quality of life. Roughly one million metal-on-metal (MoM) hip prostheses have been implanted worldwide in order to ameliorate these issues. While most MoM hip replacements are successful, some patients suffer from serious adverse effects secondary to the release of metal debris due to implant wear and corrosion. MoM hip prostheses are comprised predominantly of cobalt and chromium, and the serum concentration of these metal ions has been shown to correlate with both implant wear and the accumulation of metal debris in the periprosthetic tissue. Consequently, measurement of cobalt and chromium concentrations may be useful in the assessment of implant function and the potential for adverse effects in the follow-up of patients with MoM hip prostheses. The purpose of this Mini Review is to describe the adverse biological consequences of metal release from hip prostheses, provide an overview of the clinical utility of cobalt and chromium measurement and the current recommendations for testing, and alert laboratorians and physicians to the many challenges associated with measuring these metal ions.
引用
收藏
页码:213 / 220
页数:8
相关论文
共 41 条
[1]  
[Anonymous], 2012, MDA2012036 MED HEALT
[2]  
[Anonymous], J ARTHROPLASTY
[3]   How do serum cobalt and chromium levels change after metal-on-metal hip resurfacing? [J].
Back, DL ;
Young, AA ;
Shimmin, AJ .
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2005, (438) :177-181
[4]   High failure rates with a large-diameter hybrid metal-on-metal total hip replacement CLINICAL, RADIOLOGICAL AND RETRIEVAL ANALYSIS [J].
Bolland, B. J. R. F. ;
Culliford, D. J. ;
Langton, D. J. ;
Millington, J. P. S. ;
Arden, N. K. ;
Latham, J. M. .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2011, 93B (05) :608-615
[5]   Metal Ion Measurement as a Diagnostic Tool to Identify Problems with Metal-on-Metal Hip Resurfacing [J].
de Smet, K. ;
de Haan, R. ;
Calistri, A. ;
Campbell, P. A. ;
Ebramzadeh, E. ;
Pattyn, C. ;
Gill, H. S. .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2008, 90A :202-208
[6]   OPTIC ATROPHY FOLLOWING PROPHYLACTIC CHEMOTHERAPY AND CRANIAL RADIATION FOR ACUTE LYMPHOCYTIC LEUKEMIA [J].
FISHMAN, ML ;
BEAN, SC ;
COGAN, DG .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1976, 82 (04) :571-576
[7]   Are Metal Ion Levels a Useful Trigger for Surgical Intervention? [J].
Griffin, William L. ;
Fehring, Thomas K. ;
Kudrna, James C. ;
Schmidt, Robert H. ;
Christie, Michael J. ;
Odum, Susan M. ;
Dennos, Anne C. .
JOURNAL OF ARTHROPLASTY, 2012, 27 (08) :32-36
[8]   Sensitivity and specificity of blood cobalt and chromium metal ions for predicting failure of metal-on-metal hip replacement [J].
Hart, A. J. ;
Sabah, S. A. ;
Bandi, A. S. ;
Maggiore, P. ;
Tarassoli, P. ;
Sampson, B. ;
Skinner, J. A. .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2011, 93B (10) :1308-1313
[9]   The painful metal-on-metal hip resurfacing [J].
Hart, A. J. ;
Sabah, S. ;
Henckel, J. ;
Lewis, A. ;
Cobb, J. ;
Sampson, B. ;
Mitchell, A. ;
Skinner, J. A. .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2009, 91B (06) :738-744
[10]   Cup inclination angle of greater than 50 degrees increases whole blood concentrations of cobalt and chromium ions after metal-on-metal hip resurfacing [J].
Hart, A. J. ;
Buddhdev, P. ;
Winship, P. ;
Faria, N. ;
Powell, J. J. ;
Skinner, J. A. .
HIP INTERNATIONAL, 2008, 18 (03) :212-219