Sustainable Response of a Patient With Metastasized Pancreatic Cancer and a Hypermutational Phenotype to Immunotherapy. New Therapeutic Concept for a Rare Subtype?

被引:2
作者
Berger, Stephanie [1 ,2 ]
Bochum, Sylvia [1 ,2 ]
Finkeisen, Dora [2 ]
Schilliro, Antonella [1 ,2 ]
Autschbach, Frank [1 ]
Bischof, Marc [1 ]
Iiagmueller, Egbert [1 ]
Pereira, Philippe Lucien [1 ]
Weickert, Uwe [1 ]
Sipos, Bence [3 ]
Biskup, Saskia [4 ]
Martens, Uwe Marc [1 ,2 ]
机构
[1] SLK Clin Heilbronn, Canc Ctr Heilbronn Franken, Heilbronn, Germany
[2] MOLIT Inst Personalized Med, Heilbronn, Germany
[3] Univ Hosp Tuebingen, Tubingen, Germany
[4] Ctr Genom & Transcript, Tubingen, Germany
关键词
INTEGRATED GENOMIC CHARACTERIZATION; TUMOR-INFILTRATING LYMPHOCYTES; CTLA-4; BLOCKADE; NEOANTIGEN LOAD; PD-1; ASSOCIATION; COMBINATION; INHIBITION; EXPRESSION; LANDSCAPE;
D O I
10.1200/PO.18.00005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:1 / 6
页数:6
相关论文
共 20 条
  • [1] Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma
    Aguirre, Andrew J.
    Hruban, Ralph H.
    Raphael, Benjamin J.
    [J]. CANCER CELL, 2017, 32 (02) : 185 - +
  • [2] Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency
    Bouffet, Eric
    Larouche, Valerie
    Campbell, Brittany B.
    Merico, Daniele
    de Borja, Richard
    Aronson, Melyssa
    Durno, Carol
    Krueger, Joerg
    Cabric, Vanja
    Ramaswamy, Vijay
    Zhukova, Nataliya
    Mason, Gary
    Farah, Roula
    Afzal, Samina
    Yalon, Michal
    Rechavi, Gideon
    Magimairajan, Vanan
    Walsh, Michael F.
    Constantini, Shlomi
    Dvir, Rina
    Elhasid, Ronit
    Reddy, Alyssa
    Osborn, Michael
    Sullivan, Michael
    Hansford, Jordan
    Dodgshun, Andrew
    Klauber-Demore, Nancy
    Peterson, Lindsay
    Patel, Sunil
    Lindhorst, Scott
    Atkinson, Jeffrey
    Cohen, Zane
    Laframboise, Rachel
    Dirks, Peter
    Taylor, Michael
    Malkin, David
    Albrecht, Steffen
    Dudley, Roy W. R.
    Jabado, Nada
    Hawkins, Cynthia E.
    Shlien, Adam
    Tabori, Uri
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (19) : 2206 - +
  • [3] Comprehensive Analysis of Hypermutation in Human Cancer
    Campbell, Brittany B.
    Light, Nicholas
    Fabrizio, David
    Zatzman, Matthew
    Fuligni, Fabio
    de Borja, Richard
    Davidson, Scott
    Edwards, Melissa
    Elvin, Julia A.
    Hodel, Karl P.
    Zahurancik, Walter J.
    Suo, Zucai
    Lipman, Tatiana
    Wimmer, Katharina
    Kratz, Christian P.
    Bowers, Daniel C.
    Laetsch, Theodore W.
    Dunn, Gavin P.
    Johanns, Tanner M.
    Grimmer, Matthew R.
    Smirnov, Ivan V.
    Larouche, Valerie
    Samuel, David
    Bronsema, Annika
    Osborn, Michael
    Stearns, Duncan
    Raman, Pichai
    Cole, Kristina A.
    Storm, Phillip B.
    Yalon, Michal
    Opocher, Enrico
    Mason, Gary
    Thomas, Gregory A.
    Sabel, Magnus
    George, Ben
    Ziegler, David S.
    Lindhorst, Scott
    Issai, Vanan Magimairajan
    Constantini, Shlomi
    Toledano, Helen
    Elhasid, Ronit
    Farah, Roula
    Dvir, Rina
    Dirks, Peter
    Huang, Annie
    Galati, Melissa A.
    Chung, Jiil
    Ramaswamy, Vijay
    Irwin, Meredith S.
    Aronson, Melyssa
    [J]. CELL, 2017, 171 (05) : 1042 - +
  • [4] The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
    Cerami, Ethan
    Gao, Jianjiong
    Dogrusoz, Ugur
    Gross, Benjamin E.
    Sumer, Selcuk Onur
    Aksoy, Buelent Arman
    Jacobsen, Anders
    Byrne, Caitlin J.
    Heuer, Michael L.
    Larsson, Erik
    Antipin, Yevgeniy
    Reva, Boris
    Goldberg, Arthur P.
    Sander, Chris
    Schultz, Nikolaus
    [J]. CANCER DISCOVERY, 2012, 2 (05) : 401 - 404
  • [5] Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
    Chalmers, Zachary R.
    Connelly, Caitlin F.
    Fabrizio, David
    Gay, Laurie
    Ali, Siraj M.
    Ennis, Riley
    Schrock, Alexa
    Campbell, Brittany
    Shlien, Adam
    Chmielecki, Juliann
    Huang, Franklin
    He, Yuting
    Sun, James
    Tabori, Uri
    Kennedy, Mark
    Lieber, Daniel S.
    Roels, Steven
    White, Jared
    Otto, Geoffrey A.
    Ross, Jeffrey S.
    Garraway, Levi
    Miller, Vincent A.
    Stephens, Phillip J.
    Frampton, Garrett M.
    [J]. GENOME MEDICINE, 2017, 9
  • [6] MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade
    Ebert, Peter J. R.
    Cheung, Jeanne
    Yang, Yagai
    McNamara, Erin
    Hong, Rebecca
    Moskalenko, Marina
    Gould, Stephen E.
    Maecker, Heather
    Irving, Bryan A.
    Kim, Jeong M.
    Belvin, Marcia
    Mellman, Ira
    [J]. IMMUNITY, 2016, 44 (03) : 609 - 621
  • [7] Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
    Gao, Jianjiong
    Aksoy, Buelent Arman
    Dogrusoz, Ugur
    Dresdner, Gideon
    Gross, Benjamin
    Sumer, S. Onur
    Sun, Yichao
    Jacobsen, Anders
    Sinha, Rileen
    Larsson, Erik
    Cerami, Ethan
    Sander, Chris
    Schultz, Nikolaus
    [J]. SCIENCE SIGNALING, 2013, 6 (269) : pl1
  • [8] Integrated genomic characterization of endometrial carcinoma
    Getz, Gad
    Gabriel, Stacey B.
    Cibulskis, Kristian
    Lander, Eric
    Sivachenko, Andrey
    Sougnez, Carrie
    Lawrence, Mike
    Kandoth, Cyriac
    Dooling, David
    Fulton, Robert
    Fulton, Lucinda
    Kalicki-Veizer, Joelle
    McLellan, Michael D.
    O'Laughlin, Michelle
    Schmidt, Heather
    Wilson, Richard K.
    Ye, Kai
    Ding, Li
    Mardis, Elaine R.
    Ally, Adrian
    Balasundaram, Miruna
    Birol, Inanc
    Butterfield, Yaron S. N.
    Carlsen, Rebecca
    Carter, Candace
    Chu, Andy
    Chuah, Eric
    Chun, Hye-Jung E.
    Dhalla, Noreen
    Guin, Ranabir
    Hirst, Carrie
    Holt, Robert A.
    Jones, Steven J. M.
    Lee, Darlene
    Li, Haiyan I.
    Marra, Marco A.
    Mayo, Michael
    Moore, Richard A.
    Mungall, Andrew J.
    Plettner, Patrick
    Schein, Jacqueline E.
    Sipahimalani, Payal
    Tam, Angela
    Varhol, Richard J.
    Robertson, A. Gordon
    Pashtan, Itai
    Saksena, Gordon
    Onofrio, Robert C.
    Schumacher, Steven E.
    Tabak, Barbara
    [J]. NATURE, 2013, 497 (7447) : 67 - 73
  • [9] Guo SC, 2017, WORLD J CLIN ONCOL, V8, P230, DOI 10.5306/wjco.v8.i3.230
  • [10] Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1
    Howitt, Brooke E.
    Shukla, Sachet A.
    Sholl, Lynette M.
    Ritterhouse, Lauren L.
    Watkins, Jaclyn C.
    Rodig, Scott
    Stover, Elizabeth
    Strickland, Kyle C.
    D'Andrea, Alan D.
    Wu, Catherine J.
    Matulonis, Ursula A.
    Konstantinopoulos, Panagiotis A.
    [J]. JAMA ONCOLOGY, 2015, 1 (09) : 1319 - 1323