Role of AMPK in pancreatic beta cell function

被引：85
作者：
Fu, Accalia [1 ]
Eberhard, Chandra E. [1 ]
Screaton, Robert A. [1 ,2 ,3 ]
机构：
[1] Childrens Hosp Eastern Ontario, Res Inst, Ottawa, ON K1H 8L1, Canada
[2] Univ Ottawa, Dept Pediat, Ottawa, ON K1N 6N5, Canada
[3] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1N 6N5, Canada
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2013年 / 366卷 / 02期
关键词：
AMPK; Beta cell; Glucose stimulated insulin secretion; Pancreas; Islet; Mitochondria; ACTIVATED PROTEIN-KINASE; STIMULATED INSULIN-SECRETION; GLUCOSE-HOMEOSTASIS; IN-VIVO; HEPATIC STEATOSIS; OVER-EXPRESSION; SKELETAL-MUSCLE; KEY REGULATOR; AICA-RIBOSIDE; LKB1;
D O I：
10.1016/j.mce.2012.06.020
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Pharmacological activation of AMP activated kinase (AMPK) by metformin has proven to be a beneficial therapeutic approach for the treatment of type II diabetes. Despite improved glucose regulation achieved by administration of small molecule activators of AMPK, the potential negative impact of enhanced AMPK activity on insulin secretion by the pancreatic beta cell is an important consideration. In this review, we discuss our current understanding of the role of AMPK in central functions of the pancreatic beta cell, including glucose-stimulated insulin secretion (GSIS), proliferation, and survival. In addition we discuss the controversy surrounding the role of AMPK in insulin secretion, underscoring the merits and caveats of methods used to date. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：127 / 134
页数：8
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