Candidate miRNAs in human breast cancer biomarkers: a systematic review

被引：108

作者：

Adhami, Masoumeh ^{[1
]}

Haghdoost, Ali Akbar ^{[1
]}

Sadeghi, Balal ^{[2
]}

Afshar, Reza Malekpour ^{[3
]}

机构：

[1] Kerman Univ Med Sci, Inst Futures Studies Hlth, Modeling Hlth Res Ctr, Kerman, Iran

[2] Shahid Bahonar Univ Kerman, Food Hyg & Publ Hlth Dept, Fac Vet Med, Kerman, Iran

[3] Kerman Univ Med Sci, Pathol & Stem Cell Res Ctr, Kerman, Iran

来源：

BREAST CANCER | 2018年 / 25卷 / 02期

关键词：

Breast cancer; MicroRNA; Biomarker; Microarray; TUMOR-SUPPRESSORS; MICRORNA; EXPRESSION; MIR-21; CELLS; PROLIFERATION; MIGRATION; SURVIVAL; INVASION; MIR-145;

D O I：

10.1007/s12282-017-0814-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer (BC) is the most prevalent cancer and the main cause of cancer deaths among females around the world. For early diagnosis of BC, there would be an immediate and essential requirement to search for sensitive biomarkers. To identify candidate miRNA biomarkers for BC, we performed a general systematic review regarding the published miRNA profiling researches comparing miRNA expression level between BC and normal tissues. A miRNA ranking system was selected, which considered frequency of comparisons in direction and agreement of differential expression. We determined that two miRNAs (mir-21 and miR-210) were upregulated consistently and six miRNAs (miR-145, miR-139-5p, miR-195, miR-99a, miR-497 and miR-205) were downregulated consistently in at least three studies. MiR-21 as the most consistently reported miRNA was upregulated in six profiling studies. Although these miRNAs require being validated and further investigated, they could be potential candidates for BC miRNA biomarkers and used for early prognosis or diagnosis.

引用

页码：198 / 205

页数：8

共 60 条

[1] Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer [J].

Alder, Hansjuerg ;

Taccioli, Cristian ;

Chen, Hongping ;

Jiang, Yubao ;

Smalley, Karl J. ;

Fadda, Paolo ;

Ozer, Hatice G. ;

Huebner, Kay ;

Farber, John L. ;

Croce, Carlo M. ;

Fong, Louise Y. Y. .

CARCINOGENESIS, 2012, 33 (09) :1736-1744

[2] The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[3]

[Anonymous], PLOS ONE

[4] Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues [J].

Bandres, E. ;

Cubedo, E. ;

Agirre, X. ;

Malumbres, R. ;

Zarate, R. ;

Ramirez, N. ;

Abajo, A. ;

Navarro, A. ;

Moreno, I. ;

Monzo, M. ;

Garcia-Foncillas, J. .

MOLECULAR CANCER, 2006, 5 (1)

[5] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[6] SomamiR 2.0: a database of cancer somatic mutations altering microRNA-ceRNA interactions [J].

Bhattacharya, Anindya ;

Cui, Yan .

NUCLEIC ACIDS RESEARCH, 2016, 44 (D1) :D1005-D1010

[7] Meta-analysis of colorectal cancer gene expression profiling studies identifies consistently reported candidate biomarkers [J].

Chan, Simon K. ;

Griffith, Obi L. ;

Tai, Isabella T. ;

Jones, Steven J. M. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2008, 17 (03) :543-552

[8] Implications of micro-RNA profiling for cancer diagnosis [J].

Cummins, J. M. ;

Velculescu, V. E. .

ONCOGENE, 2006, 25 (46) :6220-6227

[9] miR-145 inhibits proliferation and migration of breast cancer cells by directly or indirectly regulating TGF-β1 expression [J].

Ding, Yanling ;

Zhang, Chunfu ;

Zhang, Jiahui ;

Zhang, Nannan ;

Li, Tao ;

Fang, Jie ;

Zhang, Yi ;

Zuo, Feiyang ;

Tao, Zehua ;

Tang, Shengnan ;

Zhu, Wei ;

Chen, Huabiao ;

Sun, Xiaochun .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2017, 50 (05) :1701-1710

[10]

Fang H, 2017, AM J TRANSL RES, V9, P953

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