Atrial Fibrillation Stroke Prevention in Older Adults

被引:4
作者
Quinn, Gene R. [2 ]
Fang, Margaret C. [1 ]
机构
[1] Univ Calif San Francisco, Div Hosp Med, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
关键词
Atrial fibrillation; Stroke prevention; Anticoagulants; Bleeding risk; CLINICAL CLASSIFICATION SCHEMES; RISK STRATIFICATION SCHEMES; FACTOR XA INHIBITOR; ANTITHROMBOTIC THERAPY; COST-EFFECTIVENESS; INTRACRANIAL HEMORRHAGE; ANTICOAGULANT-THERAPY; ORAL ANTICOAGULATION; CATHETER ABLATION; PREDICTING STROKE;
D O I
10.1016/j.cger.2012.08.003
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Atrial fibrillation (AF) is an increasingly prevalent disease in the elderly. Patients with AF are at increased risk of ischemic stroke, resulting in significant morbidity and mortality. Warfarin is highly effective at reducing stroke risk, with a net clinical benefit favoring treatment in older individuals. The advent of newer oral anticoagulants provides promising alternatives to warfarin. Appropriate risk stratification for stroke should be performed for all patients with AF to guide antithrombotic therapy. For patients at lower stroke risk, bleeding risk stratification tools can also be used when the benefit of anticoagulant therapy is unclear.
引用
收藏
页码:617 / +
页数:20
相关论文
共 77 条
[21]   Death and disability from warfarin-associated intracranial and extracranial hemorrhages [J].
Fang, Margaret C. ;
Go, Alan S. ;
Chang, Yuchiao ;
Hylek, Elaine M. ;
Henault, Lori E. ;
Jensvold, Nancy G. ;
Singer, Daniel E. .
AMERICAN JOURNAL OF MEDICINE, 2007, 120 (08) :700-705
[22]   Thirty-Day Mortality After Ischemic Stroke and Intracranial Hemorrhage in Patients With Atrial Fibrillation On and Off Anticoagulants [J].
Fang, Margaret C. ;
Go, Alan S. ;
Chang, Yuchiao ;
Borowsky, Leila H. ;
Pomernacki, Niela K. ;
Udaltsova, Natalia ;
Singer, Daniel E. .
STROKE, 2012, 43 (07) :1795-1799
[23]   A New Risk Scheme to Predict Warfarin-Associated Hemorrhage The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study [J].
Fang, Margaret C. ;
Go, Alan S. ;
Chang, Yuchiao ;
Borowsky, Leila H. ;
Pomernacki, Niela K. ;
Udaltsova, Natalia ;
Singer, Daniel E. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 58 (04) :395-401
[24]   Risks and benefits of combining aspirin with anticoagulant therapy in patients with atrial fibrillation: An exploratory analysis of stroke prevention using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) trials [J].
Flaker, Greg C. ;
Gruber, Michael ;
Connolly, Stuart J. ;
Goldman, Steven ;
Chaparro, Sandra ;
Vahanian, Alec ;
Halinen, Matti O. ;
Horrow, Jay ;
Halperin, Jonathan L. .
AMERICAN HEART JOURNAL, 2006, 152 (05) :967-973
[25]   ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation) Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society [J].
Fuster, Valentin ;
Ryden, Lars E. ;
Cannom, David S. ;
Crijns, Harry J. ;
Curtis, Anne B. ;
Ellenbogen, Kenneth A. ;
Halperin, Jonathan L. ;
Le Heuzey, Jean-Yves ;
Kay, G. Neal ;
Lowe, James E. ;
Olsson, S. Bertil ;
Prystowsky, Eric N. ;
Tamargo, Juan Luis ;
Wann, Samuel .
CIRCULATION, 2006, 114 (07) :E257-E354
[26]   COST-EFFECTIVENESS OF WARFARIN AND ASPIRIN FOR PROPHYLAXIS OF STROKE IN PATIENTS WITH NONVALVULAR ATRIAL-FIBRILLATION [J].
GAGE, BF ;
CARDINALLI, AB ;
ALBERS, GW ;
OWENS, DK .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (23) :1839-1845
[27]   Clinical classification schemes for predicting hemorrhage: Results from the National Registry of Atrial Fibrillation (NRAF) [J].
Gage, BF ;
Yan, Y ;
Milligan, PE ;
Waterman, AD ;
Culverhouse, R ;
Rich, MW ;
Radford, MJ .
AMERICAN HEART JOURNAL, 2006, 151 (03) :713-719
[28]   Incidence of intracranial hemorrhage in patients with atrial fibrillation who are prone to fall [J].
Gage, BF ;
Birman-Deych, E ;
Kerzner, R ;
Radford, MJ ;
Nilasena, DS ;
Rich, MW .
AMERICAN JOURNAL OF MEDICINE, 2005, 118 (06) :612-617
[29]   Selecting patients with atrial fibrillation for anticoagulation - Stroke risk stratification in patients taking aspirin [J].
Gage, BF ;
van Walraven, C ;
Pearce, L ;
Hart, RG ;
Koudstaal, PJ ;
Petersen, P .
CIRCULATION, 2004, 110 (16) :2287-2292
[30]   Validation of clinical classification schemes for predicting stroke - Results from the national registry of Atrial Fibrillation [J].
Gage, BF ;
Waterman, AD ;
Shannon, W ;
Boechler, M ;
Rich, MW ;
Radford, MJ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (22) :2864-2870