Rapalogs in cancer prevention Anti-aging or anticancer?

被引：64
作者：
Blagosklonny, Mikhail V. [1 ]
机构：
[1] Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY 14263 USA
来源：
CANCER BIOLOGY & THERAPY | 2012年 / 13卷 / 14期
关键词：
aging; senescence; geroconversion; gerosuppression; rapamycin; diseases; mTOR; TRANSGENIC MOUSE MODEL; AGE-RELATED DISEASES; HEALTHY LIFE-SPAN; CALORIE RESTRICTION; CELL-CYCLE; SPONTANEOUS TUMORIGENESIS; THERAPEUTIC TARGET; MTOR INHIBITION; KAPOSIS-SARCOMA; PI3K PATHWAY;
D O I：
10.4161/cbt.22859
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Common cancer is an age-related disease. Slow aging is associated with reduced and delayed carcinogenesis. Calorie restriction (CR), the most studied anti-aging intervention, prevents cancer by slowing down the aging process. Evidence is emerging that CR decelerates aging by deactivating MTOR (target of rapamycin). Rapamycin and other rapalogs suppress cellular senescence, slow down aging and postpone age-related diseases including cancer. At the same time, rapalogs are approved for certain cancer treatments. Can cancer prevention be explained by direct targeting of cancer cells? Or does rapamycin prevent cancer indirectly through slowing down the aging process? Increasing evidence points to the latter scenario.
引用
收藏
页码：1349 / 1354
页数：6
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