Hyrtimomines A-C, New Heteroaromatic Alkaloids from a Sponge Hyrtios sp.

被引：56
作者：
Momose, Rei [1 ]
Tanaka, Naonobu [1 ]
Fromont, Jane [2 ]
Kobayashi, Jun'ichi [1 ]
机构：
[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan
[2] Western Australian Museum, Weishpool Dc, WA 6986, Australia
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 08期
关键词：
INDOLE ALKALOIDS; MARINE;
D O I：
10.1021/ol400687b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three new alkaloids, hyrtimomines A-C (1-3), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1-3 were elucidated on the basis of spectroscopic analysis and application of a phenylglycine methyl ester (PGME) method. Hyrtimomines A (1) and B (2) are heteroaromatic alkaloids possessing a fused hexacyclic 6/5/6/6/7/5 ring system, while hyrtimomine C (3) is an alkaloid consisting of hydroxyindole and azepino-hydroxyindole moieties. Hyrtimomine A (1) exhibited cytotoxicity against KB and L1210 cells.
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收藏
页码：2010 / 2013
页数：4
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