Intravital imaging of host-parasite interactions in skin and adipose tissues

被引:16
作者
De Niz, Mariana [1 ,2 ,6 ]
Meehan, Gavin R. [2 ]
Brancucci, Nicolas M. B. [3 ,4 ]
Marti, Matthias [2 ]
Rotureau, Brice [5 ]
Figueiredo, Luisa M. [6 ]
Frischknecht, Friedrich [7 ]
机构
[1] Univ Bern, Inst Cell Biol, Heussler Grp, Bern, Switzerland
[2] Univ Glasgow, Wellcome Ctr Integrat Parasitol, Glasgow, Lanark, Scotland
[3] Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, Malaria Gene Regulat Unit, Basel, Switzerland
[4] Univ Basel, Basel, Switzerland
[5] Inst Pasteur, Trypanosome Transmiss Grp, INSERM,U1201, Trypanosome Cell Biol Unit,Dept Parasites & Insec, Paris, France
[6] Univ Lisbon, Inst Med Mol Joao Lobo Antunes, Fac Med, P-1649028 Lisbon, Portugal
[7] Heidelberg Univ, Med Sch, Ctr Infect Dis, Integrat Parasitol, Heidelberg, Germany
基金
欧洲研究理事会; 英国惠康基金;
关键词
LEISHMANIA-MAJOR INFECTION; TRYPANOSOMA-CONGOLENSE; PLASMODIUM-BERGHEI; SCHISTOSOMA-MANSONI; MALARIA PARASITE; SPOROZOITE TRANSMISSION; IMMUNE-RESPONSES; MICROSCOPY; MOSQUITO; INVASION;
D O I
10.1111/cmi.13023
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Intravital microscopy allows the visualisation of how pathogens interact with host cells and tissues in living animals in real time. This method has enabled key advances in our understanding of host-parasite interactions under physiological conditions. A combination of genetics, microscopy techniques, and image analysis have recently facilitated the understanding of biological phenomena in living animals at cellular and subcellular resolution. In this review, we summarise findings achieved by intravital microscopy of the skin and adipose tissues upon infection with various parasites, and we present a view into possible future applications of this method.
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页数:12
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