Antioxidant bisabolane-type sesquiterpenoids from algal-derived fungusAspergillus sydowiiEN-434

被引：15
作者：
Hu, Xueyi [1 ,2 ,3 ]
Li, Xiaoming [1 ,2 ,4 ]
Meng, Linghong [1 ,2 ,4 ]
Wang, Bingui [1 ,2 ,4 ]
机构：
[1] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
[3] Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China
[4] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
来源：
JOURNAL OF OCEANOLOGY AND LIMNOLOGY | 2020年 / 38卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Aspergillus sydowii; algal-derived fungus; bisabolene-type sesquiterpenoid; antioxidant activity; SYDONIC ACID; FUNGUS; METABOLITES;
D O I：
10.1007/s00343-020-0049-y
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A new aromatic bisabolene-type sesquiterpenoid (7S-8S)-8-hydroxysydowic acid (1), together with a pair of new bisabolene derivative (+/-)-(7R*,10R*)-10-hydroxysydowic acid (2), as well as two known analogues hydroxysydonic acid (3) and sydowic acid (4) were isolated and identified from the endophytic fungal strainAspergillus sydowiiEN-434 that was obtained from the marine red algaSymphyocladia latiuscula. Their structures were elucidated by nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectroscopy (HRESIMS), and quantum chemical electronic circular dichroism (ECD) calculations as well as comparison of the data with literature reports. Compound1exhibited potent DPPH free radical scavenging activity with IC(50)value of 113.5 mu mol/L.
引用
收藏
页码：1532 / 1536
页数：5
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