Exercise and GLUT4

被引：64

作者：

Flores-Opazo, Marcelo ^{[1
]}

McGee, Sean L. ^{[2
,3
]}

Hargreaves, Mark ^{[4
]}

机构：

[1] Univ Finis Terrae, Dept Physiotherapy, Lab Exercise & Phys Act Sci, Santiago, Chile

[2] Deakin Univ, Sch Med, Metab Res Unit, Waurn Ponds, Australia

[3] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat IMPACT, Waurn Ponds, Australia

[4] Univ Melbourne, Dept Physiol, Grattan St, Melbourne, Vic 3010, Australia

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2020年 / 48卷 / 03期

基金：

英国医学研究理事会;

关键词：

exercise; GLUT4; insulin sensitivity; skeletal muscle; muscle; glucose; HUMAN SKELETAL-MUSCLE; STIMULATED GLUCOSE-TRANSPORT; ACTIVATED PROTEIN-KINASE; MYOCYTE ENHANCER FACTOR-2; INSULIN ACTION; ENDURANCE EXERCISE; INDUCED INCREASE; MESSENGER-RNA; NITRIC-OXIDE; ADIPOSE-TISSUE;

D O I：

10.1249/JES.0000000000000224

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The glucose transporter GLUT4 is critical for skeletal muscle glucose uptake in response to insulin and muscle contraction/exercise. Exercise increases GLUT4 translocation to the sarcolemma and t-tubule and, over the longer term, total GLUT4 protein content. Here, we review key aspects of GLUT4 biology in relation to exercise, with a focus on exercise-induced GLUT4 translocation, postexercise metabolism and muscle insulin sensitivity, and exercise effects on GLUT4 expression.

引用

页码：110 / 118

页数：9

共 50 条

[41] Ca2+ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells [J].

Li, Q. ;

Zhu, X. ;

Ishikura, S. ;

Zhang, D. ;

Gao, J. ;

Sun, Y. ;

Contreras-Ferrat, A. ;

Foley, K. P. ;

Lavandero, S. ;

Yao, Z. ;

Bilan, P. J. ;

Klip, A. ;

Niu, W. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2014, 307 (02) :E209-E224

[42] The insulin-sensitive GLUT4 storage compartment is a postendocytic and heterogeneous population recruited by acute exercise [J].

Tomàs, E ;

Sevilla, L ;

Palacín, M ;

Zorzano, A .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 284 (02) :490-495

[43] Regulated dynamic subcellular GLUT4 localization revealed by proximal proteome mapping in human muscle cells [J].

Ray, Anuttoma ;

Wen, Jennifer ;

Yammine, Lucie ;

Culver, Jeff ;

Parida, Isabella Supardi ;

Garren, Jeonifer ;

Xue, Liang ;

Hales, Katherine ;

Xiang, Qing ;

Birnbaum, Morris J. ;

Zhang, Bei B. ;

Monetti, Mara ;

Mcgraw, Timothy E. .

JOURNAL OF CELL SCIENCE, 2023, 136 (23)

[44] The Effect of A Single Bout of Exercise on the mRNA Levels of Transcription Factors Regulating GLUT4 Protein Expression [J].

Cheng, I-Shiung Shiung .

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2008, 40 (05) :S456-S456

[45] Insulin stimulated GLUT4 translocation - Size is not everything! [J].

Bryant, Nia J. ;

Gould, Gwyn W. .

CURRENT OPINION IN CELL BIOLOGY, 2020, 65 :28-34

[46] GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle [J].

Aerni-Flessner, Lauren ;

Abi-Jaoude, Melissa ;

Koenig, Amanda ;

Payne, Maria ;

Hruz, Paul W. .

CARDIOVASCULAR DIABETOLOGY, 2012, 11

[47] Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes [J].

Steinbusch, Laura K. M. ;

Schwenk, Robert W. ;

Ouwens, D. Margriet ;

Diamant, Michaela ;

Glatz, Jan F. C. ;

Luiken, Joost J. F. P. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2011, 68 (15) :2525-2538

[48] SPARC interacts with AMPK and regulates GLUT4 expression [J].

Song, Haiyan ;

Guan, Yuanyuan ;

Zhang, Liping ;

Li, Kun ;

Dong, Chunli .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 396 (04) :961-966

[49] Exercise-related alterations in MCT1 and GLUT4 expressions in the liver and pancreas of rats with STZ-induced diabetes [J].

Amirkhosravi, Ladan ;

Kordestani, Zeinab ;

Nikooei, Rohollah ;

Safi, Zohreh ;

Yeganeh-Hajahmadi, Mahboobeh ;

Mirtajaddini-Goki, Maryamossadat .

JOURNAL OF DIABETES AND METABOLIC DISORDERS, 2023, 22 (02) :1355-1363

[50] Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle [J].

Ikeda, Shin-ichi ;

Tamura, Yoshifumi ;

Kakehi, Saori ;

Sanada, Hiromi ;

Kawamori, Ryuzo ;

Watada, Hirotaka .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 473 (04) :947-952

← 1 2 3 4 5 →